Title:
【発明の名称】イソチアゾロ〔5,4―b〕ピリジン誘導体
Document Type and Number:
Japanese Patent JP3068175
Kind Code:
B2
Abstract:
NEW MATERIAL:A compound expressed by formula I [R1 is lower alkyl, lower alkenyl, halogeno-lower alkyl, cycloalkyl or (substituted) phenyl; R2 is H, halogen, mono- or di-lower alkylamino or cyclic amino]. EXAMPLE:7-Cyclopropyl-6-(4-fluorophenyl)-2,3,4,7-tetrahydro-3,4- dioxoisothiazolo[5,4-b]pyridine. USE:An antimicrobial agent. PREPARATION:A 2-mercapto-4-oxonicotinic acid derivative [e.g. methyl 1- cyclopropyl-6-(4-florophenyl)-1,4-dihydro-2-mercapto-4-oxonicotinate] expressed by formula II (R is lower alkyl) is reacted with an electrophilic aminating agent (e.g. 0-alkylhydroxylamine) in the presence of a base (e.g. sodium hydroxide).
Inventors:
Yoshiro Nishimura
Hidetsugu Okada
Junichi Matsumoto
Shinichi Nakamura
Akira Minami
Hidetsugu Okada
Junichi Matsumoto
Shinichi Nakamura
Akira Minami
Application Number:
JP33269590A
Publication Date:
July 24, 2000
Filing Date:
November 28, 1990
Export Citation:
Assignee:
Dainippon Pharmaceutical Co., Ltd.
International Classes:
C07D513/04; A61K31/435; A61K31/437; A61P31/04; (IPC1-7): C07D513/04; A61K31/437; A61P31/04
Attorney, Agent or Firm:
Hiroyuki Yoshioka