Title:
【発明の名称】抗ウイルス性複素環式アザヘキサン誘導体
Document Type and Number:
Japanese Patent JP3174347
Kind Code:
B2
Abstract:
There are described compounds of formula (I*) wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubsituted or substituted by one or more lower alkoxy radicals, or C4-C8cycloalkyl, R4 is phenyl or cyclohexyl each substituted in the 4-position by unsaturated heterocyclyl that is bonded by way of a ring carbon atom, has from 5 to 8 ring atoms, contains from 1 to 4 hetero atoms selected from nitrogen, oxygen, sulfur, sulfinyl (-SO-) and sulfonyl (-SO2-) and is unsubstituted or substituted by lower alkyl or by phenyl-lower alkyl, R5, independently of R2, has one of the meanings mentioned for R2, and R6, independently of R1, is lower alkoxycarbonyl, or salts thereof, provided that at least one salt-forming group is present. The compounds are inhibitors of retroviral aspartate protease and can be used, for example, in the treatment of AIDS. They exhibit outstanding pharmacodynamic properties.
Inventors:
Alexander, Fesler
Bolt, gido
Capro, Hans-Georg
Orchid, marc
Khana, Satish Chandra
Bolt, gido
Capro, Hans-Georg
Orchid, marc
Khana, Satish Chandra
Application Number:
JP53768697A
Publication Date:
June 11, 2001
Filing Date:
April 14, 1997
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
International Classes:
A61K31/00; A61K31/38; A61K31/381; A61K31/395; A61K31/41; A61K31/42; A61K31/425; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/495; A61K31/4965; A61K31/54; A61P31/00; A61P31/18; C07C233/11; C07C233/21; C07C237/04; C07C243/12; C07C243/18; C07C251/76; C07C271/22; C07C281/02; C07C281/04; C07D213/42; C07D213/56; C07D233/64; C07D239/26; C07D241/12; C07D249/02; C07D257/04; C07D263/32; C07D277/28; C07D277/30; C07D279/12; C07D303/12; C07D303/36; C07D303/46; C07D333/20; C07D333/24; (IPC1-7): C07D213/42; C07D241/12; C07D257/04; C07D277/28; C07D333/20
Domestic Patent References:
| JP4308574A | ||||
| JP5201945A | ||||
| JP6279386A | ||||
| JP2000515147A |
Other References:
【文献】国際公開94/14436(WO,A1)
【文献】国際公開94/19332(WO,A1)
【文献】国際公開94/19332(WO,A1)
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)