Title:
【発明の名称】経皮吸収型ツロブテロール製剤の製造法
Document Type and Number:
Japanese Patent JP3260765
Kind Code:
B2
Abstract:
A percutaneous tulobuterol preparation obtained by laminating a pressure-sensitive adhesive layer comprising as the main component a synthetic rubber containing micro-crystalline tulobuterol of 2 to 20 mu m in average particle size onto a support; in particular, a percutaneous tulobuterol preparation wherein the micro-crystalline tulobuterol is one obtained by dissolving tulobuterol and a pressure-sensitive adhesive comprising as the main component a synthetic resin in a good solvent followed by recrystallization; and a process for producing the preparation which comprises homogeneously dissolving the adhesive and tulobuterol in a good solvent, applying the resulting adhesive solution onto one face of a peelable film and drying to thereby form an adhesive layer; then laminating the adhesive layer onto a support; and recrystallizing tulobuterol at 10 to 30 DEG C to thereby give an adhesive layer wherein microcrystals of 2 to 20 mu m in average particle size have been homogeneously dispersed. The preparation is excellent in the long-lasting drug effect. The above process makes it possible to efficiently produce the preparation.
Inventors:
Takeaki Nakagawa
Yoshihisa Nakano
Saburo Otsuka
Yoshihisa Nakano
Saburo Otsuka
Application Number:
JP51567897A
Publication Date:
February 25, 2002
Filing Date:
August 28, 1996
Export Citation:
Assignee:
NITTO DENKO CORPORATION
Hokuriku Pharmaceutical Co., Ltd.
Hokuriku Pharmaceutical Co., Ltd.
International Classes:
A61K9/70; A61K31/137; (IPC1-7): A61K31/137; A61K9/70; A61P11/06
Other References:
【文献】カナダ国特許第2146723号(1995)
Attorney, Agent or Firm:
Hajime Takashima
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