Title:
インシュリン状成長因子を含有する安定溶液
Document Type and Number:
Japanese Patent JP3580816
Kind Code:
B2
Abstract:
PCT No. PCT/SE94/00010 Sec. 371 Date Oct. 16, 1995 Sec. 102(e) Date Oct. 16, 1995 PCT Filed Jan. 10, 1994 PCT Pub. No. WO94/15584 PCT Pub. Date Jul. 21, 1994The invention relates to solutions containing IGF-1 or any functional analogue thereof in which pH is 5.5 to 6.5, preferably 5.7 to 6.2. The amount of phosphate as buffer substance should be in a concentration of less than 50 mmol/L Preferably the formulation is an aqueous solution of IGF-1 and phosphate as buffer substance in a concentration of 5 to 50 mmole or more preferably 5-20 mmol/L, e.g. 10 mmol/L. The solution should be isotonic. The solution gives a reduced pain upon subcutaneous injection. The invention also relates to a process for preparation of the formulation by mixing IGF-1 or any functional analogue thereof with a buffer substance giving pH 5.5 to 6.5 and an isotonic agent. It also relates to a method for treatment of a patient in need of IGF-1 or any functional analogue thereof by administering the claimed formulation.
Inventors:
Florin Robertson Ebba
Franson Jonas
Moore diana
Franson Jonas
Moore diana
Application Number:
JP51592294A
Publication Date:
October 27, 2004
Filing Date:
January 10, 1994
Export Citation:
Assignee:
Pharmacia Actibolague
International Classes:
A61K9/08; A61K9/00; A61K38/27; A61K38/30; A61K47/02; A61K47/24; (IPC1-7): A61K9/08; A61K38/27; A61K47/24
Domestic Patent References:
| JP5507278A |
Attorney, Agent or Firm:
Hideo Dobashi
Go Eto
Go Eto