Title:
水溶性パクリタキセルプロドラッグ
Document Type and Number:
Japanese Patent JP3737518
Kind Code:
B2
Abstract:
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, autoimmune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.
Inventors:
Lee, Chun
Wallace, Sydney
You, Dong-Fang
Young, david jay
Wallace, Sydney
You, Dong-Fang
Young, david jay
Application Number:
JP53273497A
Publication Date:
January 18, 2006
Filing Date:
March 11, 1997
Export Citation:
Assignee:
PG-TXL Company, L.P.
International Classes:
A61K31/785; A61K31/335; A61K31/337; A61K31/47; A61K31/4738; A61K31/4745; A61K31/70; A61K31/7042; A61K31/7048; A61K33/24; A61K47/48; A61K51/00; A61K51/04; A61L31/10; A61L31/16; A61P9/00; A61P35/00; A61P37/02; A61P43/00
Foreign References:
| WO1995011020A1 | ||||
| WO1993024476A1 |
Other References:
Int.J.Cancer(1987)39(3)p.409-413
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama