Title:
細胞へのポリアニオン性材料の導入のための新規組成物
Document Type and Number:
Japanese Patent JP3887015
Kind Code:
B2
Abstract:
The present invention provides compositions and methods which are useful for the introduction of polyanionic materials into cells. The compositions are mixtures of cationic compounds and neutral lipids which are typically formulated as liposomes. The cationic compounds are quaternary ammonium compounds wherein the nitrogen has two attached long chain alkyl groups, at least one of which is unsaturated. The methods for transfecting cells involve (a) contacting the polyanionic materials with the compositions above to form a polyanionic material-liposome complex, and (b) contacting the complex with the cells to be transfected.
Inventors:
Ansel, Stephen Michael
Mui, Barbara
Hope, Michael
Mui, Barbara
Hope, Michael
Application Number:
JP51122696A
Publication Date:
February 28, 2007
Filing Date:
September 29, 1995
Export Citation:
Assignee:
INEX Pharmaceuticals Corporation
International Classes:
A61K47/44; A61K9/127; A61K48/00; C12N15/87; C12N15/88
Domestic Patent References:
| JP6072831A | ||||
| JP5501264A |
Other References:
Ramila Philip and Robert Debs, Journal of Liposome Research, 米国,1993年,Vol.3 No.1, p.71-84
Attorney, Agent or Firm:
Takashi Ishida
Yoshio Yoshio
Toshio Toda
Masaya Nishiyama
Yoshio Yoshio
Toshio Toda
Masaya Nishiyama