アデノシンモノホスフェートデアミナーゼの新規阻害剤

Title:

アデノシンモノホスフェートデアミナーゼの新規阻害剤

Document Type and Number:

Japanese Patent JP3940810

Kind Code:

B2

Abstract:

Novel diazepine derivatives which selectively inhibit adenosine monophosphate deaminase and methods of preparing these compounds are provided. These compounds are useful in treating certain conditions in vivo which may be ameliorated by increased local concentrations of adenosine.

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Inventors:

Elion, Mark David
Bookser, Brett Carder
Kashib Hatra, Srinivas Lao
Gruever, Harry Edward

Application Number:

JP51827894A

Publication Date:

July 04, 2007

Filing Date:

February 03, 1994

Export Citation:

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Assignee:

METABASIS THERAPEUTICS, INC.

International Classes:

C07D487/04; A61K31/00; A61K31/55; A61K31/551; A61P7/02; A61P9/00; A61P9/10; A61P25/04; A61P29/00; A61P43/00

Domestic Patent References:

JP3047184A
JP2500916A
JP4091796A
JP62081387A
JP61249925A
JP61199797A
JP53130493A
JP54061177A

Foreign References:

US4117229
US4935505

Other References:

Tetrahedron Letters 22(33) pp3155-3158 (1981)
J.Med.Chem. 26 pp1478-1482 (1983)

Attorney, Agent or Firm:

Aoyama Aoi
Kyousei Tamura
Toshio Ueda

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