Title:
慢性腺維形成性肝疾患、急性肝疾患およびそれに関わる合併症の治療および予防のための非ペプチドブラジキニン拮抗剤の使用
Document Type and Number:
Japanese Patent JP4034849
Kind Code:
B2
Abstract:
Use of non-peptide bradykinin antagonists and their salts is claimed to treat chronic fibrogenetic liver disease (liver cirrhosis and liver fibrosis), acute liver disease and to prevent complications. Preferably the non-peptide bradykinin antagonist is a compound of formula (I). D-D' = X3=X2-X1=N, X4-C(R3)=N, N=C(R3)-X4, X4-CO-X4, CR3)=C(R3)-O; E = 1-4C alkyl, 1-4C alkylthio, 1-4C alkoxy (all optionally substituted by F), H, halo etc.; X1-X3 = N or optionally substituted CH; X4 = O, N or NR7; R1, R2 = H, halo, 1-4C alkyl or 1-4C alkoxy; R3 = H, halo, 1-6C alkyl, 6-12C aryl, (1-3C alkyl)(6-12C aryl), 3-5C alkenyl, 1-4C alkoxy, CO2H etc.
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Inventors:
Holger Haitiyu
Adalbert Wergner
Klaus Wylt
Max Fropot
Martin Wickel
Adalbert Wergner
Klaus Wylt
Max Fropot
Martin Wickel
Application Number:
JP13116097A
Publication Date:
January 16, 2008
Filing Date:
May 21, 1997
Export Citation:
Assignee:
Hoechst Gesellschaft Mito Beschlenktel Haftung
International Classes:
A61K31/47; A61K31/00; A61K45/00; A61K31/33; A61K31/335; A61K31/395; A61K31/4709; A61K31/495; A61K31/50; A61K31/505; A61K31/535; A61K31/54; A61P1/16; A61P43/00; C07D215/26; C07D401/12
Domestic Patent References:
| JP7002780A |
Other References:
Cleavage of high molecular weight kininogen in ascites and plasma of patients with cirrhosis,Thrombosis Research,1995年,Vol.78, No.4,277-282
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura