Title:
ビフェニル誘導体
Document Type and Number:
Japanese Patent JP4035444
Kind Code:
B2
Abstract:
Biphenyl derivatives represented by the following formula (1): wherein R<1> represents a C5-7 alkyl group, R<2> represents a substituted or unsubstituted aromatic hydrocarbon, or cycloalkyl group, R<3> represents a tetrazolyl group,-NHCOCF3, -NHSO2CF3 or -SO2NHCONHR<4> in which R<4> represents a substituted or unsubstituted aromatic hydrocarbon group, and Z represents a single bond, a C1-4 alkylene group or-SO2NH-, and salts thereof; and ACAT inhibitors and medicines containing them as active ingredients. The compounds according to the present invention possess excellent ACAT inhibitory activities, and are useful as preventives and/or therapeutics for diseases cased by the enhancement of ACAT activity, for example, hypercholesterolemia, atherosclerosis and the like.
More Like This:
Inventors:
Takayuki Namiki
Yukino Kishii
Masami Mitani
Masashi Tamai
Naoki Hiyama
Makoto Kimura
Satoshi Ichinomiya
Yukino Kishii
Masami Mitani
Masashi Tamai
Naoki Hiyama
Makoto Kimura
Satoshi Ichinomiya
Application Number:
JP2002552896A
Publication Date:
January 23, 2008
Filing Date:
December 05, 2001
Export Citation:
Assignee:
Pola Pharma Co., Ltd.
International Classes:
C07C275/30; A61K31/17; A61K31/18; A61K31/41; A61P1/00; A61P1/16; A61P3/06; A61P9/00; A61P9/10; A61P13/12; A61P43/00; C07C311/09; C07C311/60; C07D257/04
Domestic Patent References:
| JP6211814A | ||||
| JP4235149A | ||||
| JP6072985A | ||||
| JP6184086A |
Foreign References:
| WO1999012534A1 | ||||
| US5312820 |
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto