Title:
O▲上6▼-置換グアニン誘導体、それらの製造方法および腫瘍細胞の処置におけるそれらの使用
Document Type and Number:
Japanese Patent JP4054057
Kind Code:
B2
Abstract:
O &cir& _<6>-hetarylalkyl- or naphthylalkylguanine derivatives of formula (I) wherein Y is H, ribosyl, deoxyribosyl, or R"XCHR"', wherein X is O or S, R'' and R''' are alkyl, or substituted derivatives thereof; R' is H, or alkyl or hydroxyalkyl; R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hereto atom chosen from O, N or S, or a substituted derivative thereof; or (ii) naphthyl or a substituted derivative thereof; and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O &cir& _<6>-alkylguanine-DNA alkyltransferase (ATase) activity. A process for preparation of the compounds is described. The compounds have utility in combination with alkylating agents in the chemotherapeutic treatment of tumour cells.
Inventors:
McMurray, Thomas Bryan Hamilton
McElney, Robert Stanley
McCormick, Joan Elizabeth
Elder, Rhoderick Hugh
Kelly, Jane
Marfson, Jeffrey Paul
Lafferty, Joseph Anthony
Amanda Jean, Watson
Willington, Mark Andrew
McElney, Robert Stanley
McCormick, Joan Elizabeth
Elder, Rhoderick Hugh
Kelly, Jane
Marfson, Jeffrey Paul
Lafferty, Joseph Anthony
Amanda Jean, Watson
Willington, Mark Andrew
Application Number:
JP50154395A
Publication Date:
February 27, 2008
Filing Date:
June 08, 1994
Export Citation:
Assignee:
CANCER RESEARCH TECHNOLOGY LIMITED
International Classes:
C07D473/18; A61K31/52; C07D487/04; A61K31/522; A61K31/708; A61K31/76; A61P35/00; A61P43/00; C07H19/16; C07H19/167; C07H19/173
Foreign References:
| US5091430 |
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Hiroyuki Tomita
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Hiroyuki Tomita