Title:
アデノウイルスタンパク質IX、ならびにキャプシドアセンブリー、転写活性および核再組織化に関与するそのドメイン
Document Type and Number:
Japanese Patent JP4080423
Kind Code:
B2
Abstract:
Described are adenovirus pIX proteins which are modified by mutating one or more amino acids and/or by the inclusion of a binding moiety. Preferably, said modification is carried out in the N-terminal part or in the C-terminal leucine-repeat of the pIX protein. It is described that viruses or virus-like particles containing such a modified pIX protein show an improved gene delivery efficiency. Furthermore, described are corresponding adenoviral vectors, viruses or virus-like particles, host cells, complementation cell lines and methods for producing such viruses or virus-like particles. In addition, described are pharmaceutical compositions comprising an adenoviral vector, virus or virus-like particle, host cell or complementation cell line as mentioned above and therapeutical applications thereof.
Inventors:
Manuel, Rosa, Calatrava
Application Number:
JP2003500118A
Publication Date:
April 23, 2008
Filing Date:
May 29, 2002
Export Citation:
Assignee:
TRANSGENE S.A.
International Classes:
C12N15/09; A61K35/12; A61K35/76; A61K48/00; A61P43/00; C07K14/075; C12N5/10; C12N7/00; C12N15/34; C12N15/861
Foreign References:
| WO1999036545A1 |
Other References:
J. Virology, (1997), Vol. 71, No. 11, p. 8221-8229,1997年
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota