Title:
高度可溶性薬物の制御された放出のための胃滞留性の経口薬物投与形
Document Type and Number:
Japanese Patent JP4083818
Kind Code:
B2
Abstract:
Drugs are formulated as unit oral dosage forms by incorporating them into polymeric matrices comprised of hydrophilic polymers that swell upon imbibition of water to a size that is large enough to promote retention of the dosage form in the stomach during the fed mode. The oral formulation is designed for gastric retention and controlled delivery of an incorporated drug into the gastric cavity, and thus administered, the drug is released from the matrix into the gastric fluid by solution diffusion. The swollen polymeric matrix, having achieved sufficient size, remains in the gastric cavity for several hours if administered while the patient is in the fed mode, and remains intact long enough for substantially all of the drug to be released before substantial dissolution of the matrix occurs. The swelling matrix lowers the accessibility of the gastric fluid to the drug and thereby reduces the drug release rate. This process, together with diffusion retardation by selection of specific polymers, polymer molecular weights, and other variables, results in a sustained and controlled delivery rate of the drug to the gastric cavity.
Inventors:
Shell, John W.
Louis-Helm, Jenny
Louis-Helm, Jenny
Application Number:
JP50275699A
Publication Date:
April 30, 2008
Filing Date:
June 05, 1998
Export Citation:
Assignee:
Dipomed, Incorporated
International Classes:
A61K9/20; A61K9/00; A61K9/22; A61K9/26; A61K9/48; A61K31/136; A61K31/155; A61K31/335; A61K31/341; A61K31/40; A61K31/401; A61K31/4365; A61K31/70; A61K38/00; A61K47/34; A61K47/36; A61K47/38
Domestic Patent References:
| JP7507059A | ||||
| JP60218329A |
Foreign References:
| WO1996026718A1 | ||||
| WO1996032097A1 |
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji