Title:
疾病の放射性医薬品治療のための最適線量の設定装置
Document Type and Number:
Japanese Patent JP4099227
Kind Code:
B2
Abstract:
A method for determining the number of millicurie to be administered to a patient so as to deliver a given centigray (cGy) dose of either the patient's lean body of the patient's total body. The method includes the steps of injecting a radioactive tracer into a patient, determining radiation levels in the whole body, calculating a geometric mean based on the radiation levels, determining the percent-injected activity remaining in the body at each time point, plotting the percent-injected activity versus calculated time from infusion on a log-linear graph, determining the effective half-life and the rate of clearance from the log-linear graph, cross-indexing the effective half-life vlue with the patient's body weight, and multiplying the determined amount of therapeutic millicurie per centigray by the amount of desired centigray to be administered.
Inventors:
Whirl, Richard Elle.
The Sudney, Kenneth Earl.
The Sudney, Kenneth Earl.
Application Number:
JP53352996A
Publication Date:
June 11, 2008
Filing Date:
May 03, 1996
Export Citation:
Assignee:
The Regents of the University of Michigan
International Classes:
A61N5/00; A61K51/00; A61K51/10; A61N5/10
Foreign References:
| US4831122 |
Other References:
ZASADNY,K.R.ET AL, Correlation of dosimetric parameters with hematological toxicity after radioimmunotherapy of non-Hodgkin′s lymphoma with I-131 anti-B1, Utility of a new parameter:′′Total body dose-lean.′′, The Journal of Nuclear Medicine, 米国, 1995年 5月, Vol.36,No.5 Supp1., 第214頁
KAMINSKI ET AL, Radioimmunotherapy of B-Cell Lymphoma [I-131]Anti-B1 (Anti-CD20) Antibody, The New England Journal of Medicine, 米国, 1993年 8月, Vol.329,No.7, 第459-465頁
KAMINSKI ET AL, Radioimmunotherapy of B-Cell Lymphoma [I-131]Anti-B1 (Anti-CD20) Antibody, The New England Journal of Medicine, 米国, 1993年 8月, Vol.329,No.7, 第459-465頁
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio