Title:
カルシウム塩型スタチンの製造方法
Document Type and Number:
Japanese Patent JP4188826
Kind Code:
B2
Abstract:
Processes for preparing a calcium salt of a statin from an ester derivative or protected ester derivative of the statin by using calcium hydroxide are provided. The ester or protected ester derivative is contacted with calcium hydroxide to obtain the calcium salt. Preferred statins are rosuvastatin, pitavastatin and atorvastatin, simvastatin and lovastatin. In processes beginning with a protected satin ester derivative, the protecting group is hydrolyzed during salt formation by contact with calcium hydroxide, or is contacted with an acid catalyst followed by contact with calcium hydroxide.
Inventors:
Nidam-Hildesheim, Valerie
Lifshits-Lillon, Revital
Ridol-Hadas, Rami
Lifshits-Lillon, Revital
Ridol-Hadas, Rami
Application Number:
JP2003521239A
Publication Date:
December 03, 2008
Filing Date:
August 16, 2002
Export Citation:
Assignee:
Teva Pharmaceutical Industries Limited
International Classes:
C07C67/28; A61K31/22; C07D209/24; A61K31/351; A61K31/40; A61K31/404; A61K31/4418; A61K31/47; A61K31/4965; A61K31/505; A61P3/06; A61P9/10; C07B61/00; C07C69/013; C07C69/30; C07D207/34; C07D213/55; C07D215/14; C07D239/42; C07D309/30; C07F3/04
Domestic Patent References:
| JP53056314A | ||||
| JP2004514687A |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama