Title:
ペプチド
Document Type and Number:
Japanese Patent JP4223553
Kind Code:
B2
Abstract:
The invention provides novel beta-peptides comprising 2 or more different beta-amino acid residues, preferably compounds of formula Iwherein the R residues, X and n are as defined. Compounds of the invention having as few as 5 or 6 beta-amino acid residues exhibit stable structures in solution and the compounds generally exhibit good resistance to proteolytic degradation. The compounds of the invention provide a valuable new source of structural diversity for synthesis of biologically active compounds, e.g. for pharmaceutical uses.
Inventors:
Seebach, Dieter
Application Number:
JP50121498A
Publication Date:
February 12, 2009
Filing Date:
June 12, 1997
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
A61K31/16; A61K31/325; C07C237/22; A61K31/435; C07B61/00; C07C271/22
Foreign References:
| WO1994020457A1 |
Other References:
Int.J.Peptide Protein Res., 1986年, 28, p.67-78
J.CHEM.SOC.PERKIN TRANS.I, 1982年, p.1587-1592
J.POLM.SCI., 1979年, 17(7), p.1911-1921
Acta Chimica Academiae Scientiarum Hungaricae, 1976年, 83(3), p.301-308
J.MATHEMAT.SCI., 1974年, 1(1), p.21-28
Chem.Pharm.Bull., 1972年, 20(3), p.601-604
J.CHEM.SOC.PERKIN TRANS.I, 1972年, p.605-611
Chem.Ber., 1956年, 89, p.1608-1614
J.PRAKT.CHEM., 1968年, 38, p.88-100
J.CHEM.SOC.PERKIN TRANS.I, 1986年, p.155-156
J.CHEM.SOC.PERKIN TRANS.I, 1982年, p.1587-1592
J.POLM.SCI., 1979年, 17(7), p.1911-1921
Acta Chimica Academiae Scientiarum Hungaricae, 1976年, 83(3), p.301-308
J.MATHEMAT.SCI., 1974年, 1(1), p.21-28
Chem.Pharm.Bull., 1972年, 20(3), p.601-604
J.CHEM.SOC.PERKIN TRANS.I, 1972年, p.605-611
Chem.Ber., 1956年, 89, p.1608-1614
J.PRAKT.CHEM., 1968年, 38, p.88-100
J.CHEM.SOC.PERKIN TRANS.I, 1986年, p.155-156
Attorney, Agent or Firm:
Aoyama Aoi
Kazuaki Kojima
Mitsutaka Iwasaki
Kazuaki Kojima
Mitsutaka Iwasaki