Title:
改変された腫瘍壊死因子
Document Type and Number:
Japanese Patent JP4295831
Kind Code:
B2
Abstract:
Modifying TNF with polyethyleneglycol (PEG) having an approximate weight average molecular weight in the range of about 10,000 to about 40,000, preferably in the range of about 20,000 to 30,000, significantly increases the circulating half-life of the TNF while not increasing its toxicity. As a result, lower doses of the TNF may be administered to effectively treat tumors with fewer, accompanying adverse side effects to the patient.
Inventors:
Clark, Mike A
Application Number:
JP53448898A
Publication Date:
July 15, 2009
Filing Date:
January 15, 1998
Export Citation:
Assignee:
Polaris Group
International Classes:
A61K38/00; C07K14/525; A61K38/19; A61K38/22; A61P35/00
Other References:
British J. Cancer, (1996), Vol. 74, p. 1090-1095
Attorney, Agent or Firm:
Patent business corporation Odashima patent office
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