Title:
増殖性ヒト肝細胞を認識する抗体と、増殖性ヒト肝細胞および機能性ヒト肝細胞
Document Type and Number:
Japanese Patent JP4334358
Kind Code:
B2
Abstract:
Transplanting human hepatocytes into a liver of an immunodeficient hepatopathy mouse, and then feeding the mouse transplanted with the human hepatocytes under such a condition as being protected from the attack by human complement produced by the human hepatocytes thereby proliferating the transplanted human hepatocytes in the mouse liver. Further, Obtaining human hepatocytes in large scale by repeating the above steps using the proliferated human hepatocytes.
Inventors:
Tomoyo Mukaiya
Yoshizato victory
Chihiro Yamazaki
Yoshizato victory
Chihiro Yamazaki
Application Number:
JP2003578423A
Publication Date:
September 30, 2009
Filing Date:
March 25, 2003
Export Citation:
Assignee:
Hiroshima Industrial Promotion Organization
International Classes:
C07K16/18; C07K16/28; C12N5/07; C12N5/071; C12N5/10; C12N5/18; C12N5/20; C12P21/08; C12N15/02; C12N15/09
Domestic Patent References:
| JP8112092A | ||||
| JP61189299A |
Foreign References:
| WO2000003001A1 | ||||
| WO2000043498A1 | ||||
| WO1996032418A1 |
Other References:
Hepatology,2001年,Vol.33, No.3,pp.668-675
J. Lipid Res.,2000年,Vol.41, No.1,pp.1-11
Nucleic Acids Res.,2001年,Vol.29, No.5,pp.1047-1053
Biology of the cell,1994年,Vol.81, No.1,pp.77-81
J. Lipid Res.,2000年,Vol.41, No.1,pp.1-11
Nucleic Acids Res.,2001年,Vol.29, No.5,pp.1047-1053
Biology of the cell,1994年,Vol.81, No.1,pp.77-81
Attorney, Agent or Firm:
Toshio Nishizawa