Title:
エポネマイシンおよびエポキソマイシン類似物およびそれらの用途
Document Type and Number:
Japanese Patent JP4412586
Kind Code:
B2
Abstract:
The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, A, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of cancer and/or inflammatory disorders, and more generally as proteasome inhibitors.
Inventors:
Agornik, Sagel
Kozo Akasaka
Fan, frank
Hermanje, Jean-Christophe
Hawkins, Lynn
Jean, Emin
Johannes, Charles
Lee, Shan-e
McGuinness, Pamela
Murphy, Erin A.
Schiller, Shawn
Bermeulen, Mary
Woo, jay
Kozo Akasaka
Fan, frank
Hermanje, Jean-Christophe
Hawkins, Lynn
Jean, Emin
Johannes, Charles
Lee, Shan-e
McGuinness, Pamela
Murphy, Erin A.
Schiller, Shawn
Bermeulen, Mary
Woo, jay
Application Number:
JP2003560001A
Publication Date:
February 10, 2010
Filing Date:
January 08, 2003
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
C07D303/14; C07D303/36; A61K31/165; A61K31/166; A61K31/167; A61K31/336; A61K31/343; A61K31/353; A61K31/36; A61K31/40; A61K31/4025; A61K31/4035; A61K31/4045; A61K31/4427; A61K31/4709; A61K31/4725; A61K31/497; A61K31/498; A61K31/662; A61K31/69; A61P29/00; A61P31/18; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07C233/76; C07C235/82; C07C237/06; C07C237/08; C07C271/22; C07D209/48; C07D405/12; C07D407/12; C07F5/02; C07F9/655; C07K5/078; A61K38/00
Domestic Patent References:
| JP10510245A | ||||
| JP9511501A |
Foreign References:
| WO2003033506A1 |
Other References:
ELOFSSON M,CHEMISTRY AND BIOLOGY,英国,1995年,V6 N11,P811-822
GARDNER, ROBERT C.,BIOCHEMICAL JOURNAL,2000年,V346 N2,P447-454
GARDNER, ROBERT C.,BIOCHEMICAL JOURNAL,2000年,V346 N2,P447-454
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita