Title:
CS4―CFA/Iファミリータンパク質のコンセンサスペプチドに対する抗体に応答性のペプチド
Document Type and Number:
Japanese Patent JP4484968
Kind Code:
B2
Abstract:
This invention relates to amino acid sequences from within a consensus peptide of the formula: VEKNITVTASVDPTIDLLQADGSALPSAVALTYSPA (Seq. #1). Eight mer peptides from within the consensus peptide were tested against an antibody raised to the consensus peptide. Studies relating to antibody raised to denatured proteins from the natural organisms producing the family of proteins were also useful and showed particular value of some sequences. A sequence of the formula ASVDPTIDLLQA (Seq. #2) was identified thereby. An enlarged sequence of the formula TVTASVDPTIDLLQAD (Seq. #3) is also especially interesting as are intermediate sequences such as sequences VTASVDPTIDLLQAD (Seq. #4), TASVDPTIDLLQAD (Seq. #5), and TASVDPTIDLLQA (Seq. #6) as being binding sites for antibodies raised to the denatured proteins.
Inventors:
Casselus, Frederick
Loomis-Price, Lawrence
Loomis-Price, Lawrence
Application Number:
JP50805798A
Publication Date:
June 16, 2010
Filing Date:
August 01, 1997
Export Citation:
Assignee:
Department of the Army, USS Government
International Classes:
C07K2/00; G01N33/53; A61K38/00; A61K38/08; A61K38/10; A61K39/39; A61K39/395; A61P31/04; C07K4/00; C07K7/00; C07K7/06; C07K7/08; C07K14/245; C07K16/00; C07K16/12; C12N1/00; C12P21/08; A61K39/00
Other References:
Infect. Immun.,, 1994年, Vol.62, No.10, p. 4339-4346
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita