Title:
MRI用造影剤
Document Type and Number:
Japanese Patent JP4569875
Kind Code:
B2
Abstract:
Disclosed is an MRI contrast agent which enables direct detection and imaging of exfoliated vascular endothelial sites. The MRI contrast agent comprises an imaging unit which contains an unpaired electron-carrying atom and/or molecule and is capable of amplifying or reducing MRI signals, and a detection unit which is bonded to said imaging unit and is capable of selectively recognizing exfoliated vascular endothelial sites and binding thereto. The detection unit is exemplified by one having a chemical structure expressed by the following formula (I), wherein at least one of R<1>-R<11> is, for example, sulfonic acid group, and X is, for example, a phenyl group which may be substituted:
Inventors:
Yoshiki Katayama
Hiroaki Shimokawa
Tatsuhiro Yamamoto
Hiroaki Shimokawa
Tatsuhiro Yamamoto
Application Number:
JP2005502822A
Publication Date:
October 27, 2010
Filing Date:
February 03, 2004
Export Citation:
Assignee:
Kyushu University
International Classes:
A61K49/00; A61K49/10
Domestic Patent References:
| JP7145038A | ||||
| JP9208599A | ||||
| JP5507276A | ||||
| JP2002348235A |
Other References:
FLACKE,S. et al,Novel MRI contrast agent for molecular imaging of fibrin: implications for detecting vulnerable plaques,Circulation,2001年,Vol.104, No.11,p.1280-5
Attorney, Agent or Firm:
Satoshi Tsutsui