Title:
活性剤を送達するための二ナトリウム塩、一水和物、およびエタノール溶媒和物
Document Type and Number:
Japanese Patent JP4588221
Kind Code:
B2
Abstract:
The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
Inventors:
William E. Bay
Rajesh Kay Agarwal
Kiran Choudary
Singai Majuru
Michael M. Goldberg
Joanne Pie Russo
Rajesh Kay Agarwal
Kiran Choudary
Singai Majuru
Michael M. Goldberg
Joanne Pie Russo
Application Number:
JP2000609376A
Publication Date:
November 24, 2010
Filing Date:
April 05, 2000
Export Citation:
Assignee:
Emisfair Technologies Inc.
International Classes:
A61K47/16; A61K9/08; C07C235/60; A61K9/20; A61K9/48; A61K31/726; A61K38/22; A61K47/12; A61K47/18; A61P3/14; A61P7/02; C07C231/00; C07C231/12; C07D265/26; C07C235/58
Domestic Patent References:
JP10152441A | ||||
JP10507762A | ||||
JP2001513080A | ||||
JP2002506418A | ||||
JP2001524109A |
Foreign References:
ES369853A1 |
Other References:
BAUGHMAN,R.A. et al,Oral delivery of anticoagulant doses of heparin. A randomized, double-blind, controlled study in humans,Circulation,1998年,Vol.98, No.16,p.1610-1615
GONZE,M.D. et al,Orally administered heparin with a carrier agent is therapeutic for deep venous thrombosis treatment,Surgical Forum,1998年,Vol.49,p.335-337
GONZE,M.D. et al,Orally administered heparin with a carrier agent is therapeutic for deep venous thrombosis treatment,Surgical Forum,1998年,Vol.49,p.335-337
Attorney, Agent or Firm:
Masatake Shiga
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro