Title:
ADP-受容体抗血小板物質と抗高血圧薬の組合せ投与による脳梗塞の予防
Document Type and Number:
Japanese Patent JP4588877
Kind Code:
B2
Abstract:
A method is provided for preventing a cerebral infarction by administering to a patient a combination of an ADP-receptor blocking antiplatelet drug, such as clopidogrel, in combination with an antihypertensive agent such as an angiotensin AII antagonist (for example, irbesartan), an ACE inhibitor (for example, fosinopril) or a NEP/ACE inhibitor such as omapatrilat.
Inventors:
Anthony A. Coniglio
Francis Earl Pratt
Melvin S. Blumental
Francis Earl Pratt
Melvin S. Blumental
Application Number:
JP2000554379A
Publication Date:
December 01, 2010
Filing Date:
June 09, 1999
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/41; A61K45/06; A61K31/40; A61K31/401; A61K31/403; A61K31/415; A61K31/4178; A61K31/4184; A61K31/435; A61K31/4365; A61K31/44; A61K31/445; A61K31/4535; A61K31/472; A61K31/55; A61K31/554; A61K31/675; A61K38/55; A61P9/10; A61P25/00; A61P43/00
Domestic Patent References:
| JP5279257A |
Other References:
UMEMURA,K. et al,Anti-platelet effects of clopidogrel in rat middle cerebral artery thrombosis model,Thrombosis Research,1995年,Vol.80, No.3,p.209-16
UCHIYAMA,S. et al,Combination therapy with low-dose aspirin and ticlopidine in cerebral ischemia,Stroke,1989年,Vol.20, No.12,p.1643-7
FERNANDEZ,L.A. et al,Angiotensin AT2 receptor stimulation increases survival in gerbils with abrupt unilateral carotid ligation,J Cardiovasc Pharmacol,1994年,Vol.24, No.6,p.937-40
FUJII,K. et al,Effect of antihypertensive treatment on focal cerebral infarction,Hypertension,1992年,Vol.19, No.6 Pt 2,p.713-6
塩之入 洋,アンジオテンシン変換酵素,日本臨床,1992年,Vol.50, 増刊号,pp743-752
Faiez Zannad,Antihypertensive drugs ,Side Effects of Drugs Annual,1997年,Vol.20,p.194-199
UCHIYAMA,S. et al,Combination therapy with low-dose aspirin and ticlopidine in cerebral ischemia,Stroke,1989年,Vol.20, No.12,p.1643-7
FERNANDEZ,L.A. et al,Angiotensin AT2 receptor stimulation increases survival in gerbils with abrupt unilateral carotid ligation,J Cardiovasc Pharmacol,1994年,Vol.24, No.6,p.937-40
FUJII,K. et al,Effect of antihypertensive treatment on focal cerebral infarction,Hypertension,1992年,Vol.19, No.6 Pt 2,p.713-6
塩之入 洋,アンジオテンシン変換酵素,日本臨床,1992年,Vol.50, 増刊号,pp743-752
Faiez Zannad,Antihypertensive drugs ,Side Effects of Drugs Annual,1997年,Vol.20,p.194-199
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka