Title:
血清サンプル中のペプシノーゲンI(PGI)とガストリン-17の濃度の定量的測定の段階を含む、消化性潰瘍の危険性を評価する方法
Document Type and Number:
Japanese Patent JP4598959
Kind Code:
B2
Abstract:
The present invention concerns a method for assessing the risk of peptic ulcer by determining the presence and topographic phenotype of gastritis in an individual, by determining quantitatively the pepsinogen I and gastin-17 concentrations in a serum sample from the said individual, selecting a method-specific reference value and cut-off value for respective analyte, assessing the topography and phenotype of gastritis based on a comparison of the pepsinogen I and gastrin-17 concentrations so determined with their respective method-specific reference and cut-off values, and correlating the so assessed gastritis phenotype with the risk for peptic ulcer. Preferably also Helicobacter antibodies are determined in the sample.
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Inventors:
Pentti Sipponen
Matty Herkenen
Osmo Suovaniemi
Eric Forsblom
Matty Herkenen
Osmo Suovaniemi
Eric Forsblom
Application Number:
JP2000615822A
Publication Date:
December 15, 2010
Filing Date:
April 28, 2000
Export Citation:
Assignee:
BIOHIT OYJ
International Classes:
G01N33/573; G01N33/543; G01N33/577; G01N33/68; G01N33/74
Domestic Patent References:
| JP7304800A | ||||
| JP10148636A | ||||
| JP10509795A |
Other References:
TSENG-SHING CHEN et al.,Effect of Eradication of Helicobacter pylori on Serum Pepsinogen I, Gastrin, and Insulin in Duodenal Ulcer Patients: A 12-month Follow-up Study,The American Journal of Gastroenterology,1994年,Vol.89. No.9,P.1511-1514
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Mitsutaka Iwasaki