Title:
N-(4-トリフルオロメチルフェニル)-5-メチルイソキサゾール-4-カルボキサミドの結晶化方法
Document Type and Number:
Japanese Patent JP4625187
Kind Code:
B2
Abstract:
The invention relates to a process for obtaining N-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide in crystalline form, which is essentially free of byproducts. For this purpose, N-(4-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide is transferred into an organic solvent or into mixtures of organic solvents and water, the amount of byproduct in the solution is determined by quantitative analysis and an equimolar amount of a base is added. N-(4-Trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide is isolated from the resulting solution by crystallization.
Inventors:
Hans-Hermann Lau
Oud Hateman
Holger Firsch
Andreas Gapish
Oud Hateman
Holger Firsch
Andreas Gapish
Application Number:
JP2000600994A
Publication Date:
February 02, 2011
Filing Date:
February 12, 2000
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07D261/18
Domestic Patent References:
| JP62072614A | ||||
| JP55083767A | ||||
| JP5208909A |
Attorney, Agent or Firm:
Junji Yuda
Chika Takagi
Kosuke Nishimura
Chika Takagi
Kosuke Nishimura