Title:
プロスタサイクリン合成酵素遺伝子含有医薬組成物
Document Type and Number:
Japanese Patent JP4632481
Kind Code:
B2
Abstract:
The present invention relates to: pharmaceutical compositions for inducing apoptosis in cells, the pharmaceutical compositions comprising a prostacyclin synthase gene as an active ingredient; pharmaceutical compositions for gene therapy of cancer, the pharmaceutical compositions comprising the above pharmaceutical compositions for inducing apoptosis as an active ingredient; and a screening method for an agent that induces apoptosis in a cell, the method comprising determining the activation of peroxisome proliferator-activated receptor (PPAR)-delta in the presence of a test substance. The pharmaceutical composition of the present invention for inducing apoptosis enables treatment of diseases on which induction of apoptosis has a therapeutic effect. In addition, the pharmaceutical composition of the present invention for gene therapy can lead cancer cells to cell death. Furthermore, the screening method of the present invention can be used conveniently to screen for agents capable of inducing apoptosis.
Inventors:
Tadashi Tanabe
Toshihisa Hatae
Toshihisa Hatae
Application Number:
JP2000150648A
Publication Date:
February 16, 2011
Filing Date:
May 22, 2000
Export Citation:
Assignee:
Tadashi Tanabe
International Classes:
A61K48/00; A61K38/43; A61K38/44; A61P35/00; A61P43/00; C12N15/09; C12Q1/68; G01N33/15; G01N33/50
Foreign References:
| WO1995030013A1 |
Other References:
田辺忠,循環器疾患への遺伝子治療 『抗動脈硬化性不安定生理活性物質PGI2による遺伝子治療』,医学のあゆみ,日本,2000年 1月15日,Vol.192,No.3,P.239
青木元邦 他1名,虚血性心疾患治療における21世紀への課題 『冠動脈病変への遺伝子治療』,医学のあゆみ,日本,2000年 1月 1日,Vol.192,No.1,P.116-120
Hara,S. et al.,Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells,Biochem. Biophys. Res. Commun.,1995年11月22日,Vol.216,No.3,P.862-867
青木元邦 他1名,虚血性心疾患治療における21世紀への課題 『冠動脈病変への遺伝子治療』,医学のあゆみ,日本,2000年 1月 1日,Vol.192,No.1,P.116-120
Hara,S. et al.,Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cells,Biochem. Biophys. Res. Commun.,1995年11月22日,Vol.216,No.3,P.862-867
Attorney, Agent or Firm:
Eiichi Tamura