Title:
ヘテロアリール環状アセタール類
Document Type and Number:
Japanese Patent JP4634613
Kind Code:
B2
Abstract:
Compounds of formula (I) are described in which Het is a five or six membered heteroaromatic ring of the formula in which one of R1 and R2 is optionally substituted heteroaryl and the other is optionally substituted heteroaryl or optionally substituted aryl; X1 is a bond, X3 and X4 are each independently N or C and X2 and X5 are independently CH, N, NH, O or S; or X3 and X4 are C, one of X1, X2 and X5 is N and the others are N or CH; but excluding compounds in which X1 is a bond, one of X2 and X5 is N and the other is NH and X3 and X4 are both C; R3 represents a group -L1-R6; R4 represents hydrogen, alkyl or hydroxyalkyl; or R3 and R4, when attached to the same carbon atom, may form with the said carbon atom a cycloalkyl, cycloalkenyl or heterocycloalkyl ring or a group C-CH2; R5 represents hydrogen or alkyl; and m is zero or an integer 1 or 2; and N-oxides thereof, and their prodrugs; and pharmaceutically acceptable salts and solvates of compounds of formula (I) and N-oxides thereof, and their prodrugs. The compounds are TNF inhibitors and are useful as pharmaceuticals.
Inventors:
Alan John Collis
Frank Halley
Ian McFarlan McRae
Frank Halley
Ian McFarlan McRae
Application Number:
JP2000588171A
Publication Date:
February 16, 2011
Filing Date:
December 16, 1999
Export Citation:
Assignee:
Aventis Fuma Limited
International Classes:
C07D405/14; A61K31/4439; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61P3/04; A61P3/10; A61P9/10; A61P11/06; A61P19/02; A61P27/02; A61P35/00; A61P43/00; C07D409/14; C07D413/14
Domestic Patent References:
| JP2002503245A | ||||
| JP10509140A |
Foreign References:
| EP0506437A1 |
Attorney, Agent or Firm:
Junji Yuda
Chika Takagi
Kosuke Nishimura
Chika Takagi
Kosuke Nishimura