Title:
消化管下部溶解性コーティング製剤
Document Type and Number:
Japanese Patent JP4641696
Kind Code:
B2
Abstract:
A coating dispersion soluble in the lower digestive tract which is prepared by blending a hydroxypropyl methylcellulose acetate succinate (HPMCAS) soluble at around pH 7 with a conventional plasticizer and an anion surfactant and further adding an acid, wherein the HPMCAS has an average particle size of 10 mum or less and is dispersed at a concentration of 2 to 20% by weight, and the acid is used in an amount of 1 to 10 parts by weight per 100 parts by weight of HPMCAS, and a sustained release coated preparation capable of releasing a medicament in the large intestine at the lower digestive tract, which is prepared by coating a medicament-containing solid preparation such as a granular core with the coating dispersion.
Inventors:
Masashi Mukai
Daisuke Kuribayashi
Daisuke Kuribayashi
Application Number:
JP2001526209A
Publication Date:
March 02, 2011
Filing Date:
September 22, 2000
Export Citation:
Assignee:
Otsuka Pharmaceutical Co., Ltd.
International Classes:
A61K47/38; A61K9/08; A61K9/36; A61K9/50; A61K31/4709; A61K47/12; A61K47/14; A61K47/20; A61P7/02; A61P9/08; C07D401/12
Domestic Patent References:
| JPH07109219A | 1995-04-25 | |||
| JPH02289512A | 1990-11-29 | |||
| JPH07109219A | 1995-04-25 | |||
| JPH02289512A | 1990-11-29 |
Foreign References:
| WO1998016206A1 | 1998-04-23 | |||
| WO1998016206A1 | 1998-04-23 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Samejima Mutsumi
Masahiro Nitta