Title:
トロンビンレセプターアンタゴニスト
Document Type and Number:
Japanese Patent JP4642318
Kind Code:
B2
Abstract:
Heterocyclic-substituted compounds of formula (I) or a pharmaceutically acceptable salt thereof, are disclosed, wherein: Z is - (CH2)n-; (a); (b), wherein R 10 is absent; or, (c) wherein R 3 is absent; the single dotted line represents an optional double bond; the double dotted line represents an optional single bond; n is 0-2; Het is an optionally substituted mono-, bi- or tri-cyclic heteroaromatic group; B is -(CH 2 ) n3 -. wherein n 3 is 0-5, -CH 2 -O-, -CH 2 S-, -CH 2 -NR 6 -, -C(O)NR 6 -. -NR 6 C(O)-, (d), optionally substituted alkenyl or optionally substituted alkynyl; X is -O- or -NR 6 - when the double dotted line represents a single bond, or X is H, -OH or -NHR 20 when the bond is absent; Y is =O, =S, (H, H), (H, OH) or (H, C 1 -C 6 alkoxy) when the double dotted line represents a single bond or when the bond is absent, Y is =O, =NOR 17 (H, H). (H, OH), (H, SH), (H, C 1 -C 6 alkoxy) or (H, substituted-amino); R 22 and R 23 are independently -OH, -OC(O)R 30 , OC(O)NR 30 R 31 , or optionally substituted alkyl, alkenyl, alkynyl, heterocycloalkyl, aryl, cycloalkyl, cycloalkenyl, carbonyl, amino, alkoxy, alkenyloxy, alkynyloxy, heterocycloalkyloxy, cycloalkyloxy, or cycloalkenyloxy; or R 22 and R 10 , or R 23 and R 11 , can form a carbocyclic or heterocyclic ring; and the remaining variables are as described in the specification, Also disclosed are pharmaceutical compositions containing said compounds and their use as thrombin receptor antagonists and blinders to cannabinoid receptors.
Inventors:
Chuck Ala Manil, Samuel
Charlie, Mariappan
Sha, Yang
Charlie, Mariappan
Sha, Yang
Application Number:
JP2002510472A
Publication Date:
March 02, 2011
Filing Date:
June 13, 2001
Export Citation:
Assignee:
Schering Corporation
International Classes:
C07D405/06; A61K31/443; A61K31/4436; A61K31/4439; A61K31/444; A61K31/497; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P19/02; A61P19/10; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D521/00
Foreign References:
| WO1999026943A1 | ||||
| US6063847 |
Other References:
藤田稔夫、化学増刊107 構造活性相関とドラッグデザイン、1986年、第8-11頁
C.G.WERMUTH、最新 創薬化学 上巻、1998年、第1版第1刷、第287-289頁
C.G.WERMUTH、最新 創薬化学 上巻、1998年、第1版第1刷、第287-289頁
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita