Title:
2,4-ピリミジンジアミン化合物とその用途
Document Type and Number:
Japanese Patent JP4658477
Kind Code:
B2
Abstract:
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signalling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signalling cascades.
Inventors:
Shin, Razinder
Argade, Ankush
Payyan, Donald G.
Morineau, Susan
Holland, Sacha Jay.
Claw, jeffrey
Came, Holger
Bamidy Patty, Somerska
Sylvan, Catherine
Li, Hui
Rossi, Alexander Bee.
Argade, Ankush
Payyan, Donald G.
Morineau, Susan
Holland, Sacha Jay.
Claw, jeffrey
Came, Holger
Bamidy Patty, Somerska
Sylvan, Catherine
Li, Hui
Rossi, Alexander Bee.
Application Number:
JP2003563490A
Publication Date:
March 23, 2011
Filing Date:
January 31, 2003
Export Citation:
Assignee:
Rigel Pharmaceuticals, Inc.
International Classes:
C07D239/48; A61K31/505; A61K31/506; A61K31/519; A61K31/5377; A61P1/00; A61P11/06; A61P17/00; A61P27/02; A61P27/14; A61P27/16; A61P29/00; A61P37/08; A61P43/00; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14
Domestic Patent References:
| JP3127790A | ||||
| JP60072867A | ||||
| JP62286973A | ||||
| JP2004535447A | ||||
| JP2004535414A | ||||
| JP2005505535A |
Foreign References:
| WO1999031073A1 | ||||
| WO2001060816A1 | ||||
| US5958935 | ||||
| WO2000058305A1 | ||||
| WO2000039101A1 | ||||
| WO2001047897A1 | ||||
| WO2001085699A1 | ||||
| WO2001064656A1 | ||||
| WO2001022938A1 | ||||
| WO2001023362A1 | ||||
| WO2000027825A1 | ||||
| WO1999050250A1 | ||||
| WO1991018887A1 | ||||
| WO2002004429A1 |
Other References:
LUDOVICI, D. W. et al,Evolution of anti-hiv drug candidates.Part 3:diarylpyrimidine analogues,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2001年,vol. 11,p.2235-2239
GHOSH, G.,2,4-bis(arylamino)-6-methyl pyrimidines as antimicrobial agents,J. INDIAN CHEM. SOC,1981年,vol. LVIII,p.512-513
EL-KERDAWY, M. M. et al,2,4-bis(substituted)-5-nitropyrimidines of expected diuretic action,EGYPT. J. CHEM.,1987年,vol. 29, no. 2,p.247-251
KUZ'MENKO,I.I. et al,The 2-and 4-substituted 5-fluoropyrimidines,Khimiya Geterotsiklicheskikh Soedinenii,1973年,No.1,p.117-19
CHKHIKVADZE,K.A. et al,5-Substituted pyrimidines. II. Synthesis of 5,6-dihydropyrrolo[2,3-d]pyrimidines (5,7-diazaindolines),Khimiya Geterotsiklicheskikh Soedinenii,1969年,No.1,p.138-44
BANKS,R.E. et al,Studies in azide chemistry. Part IX. Investigations involving fluorinated azidopyrimidines and 4-azido-3-chloro-2,5,6-trifluoropyridine,Journal of Fluorine Chemistry,1980年,Vol.16, No.4,p.325-38
MOKHORT,N.A.,Search for non-steroid antiinflammatory substances among heterocyclic anthranilic acid derivatives,Farmatsevtichnii Zhurnal(Kiev),1970年,Vol.25, No.4,p.76-7
BANKS,R.E. et al,Heterocyclic polyfluoro compounds. X. Nucleophilic substitution in tetrafluoropyrimidine,Journal of the Chemical Society [Section] C: Organic,1967年,No.19,p.1822-6
GHOSH, G.,2,4-bis(arylamino)-6-methyl pyrimidines as antimicrobial agents,J. INDIAN CHEM. SOC,1981年,vol. LVIII,p.512-513
EL-KERDAWY, M. M. et al,2,4-bis(substituted)-5-nitropyrimidines of expected diuretic action,EGYPT. J. CHEM.,1987年,vol. 29, no. 2,p.247-251
KUZ'MENKO,I.I. et al,The 2-and 4-substituted 5-fluoropyrimidines,Khimiya Geterotsiklicheskikh Soedinenii,1973年,No.1,p.117-19
CHKHIKVADZE,K.A. et al,5-Substituted pyrimidines. II. Synthesis of 5,6-dihydropyrrolo[2,3-d]pyrimidines (5,7-diazaindolines),Khimiya Geterotsiklicheskikh Soedinenii,1969年,No.1,p.138-44
BANKS,R.E. et al,Studies in azide chemistry. Part IX. Investigations involving fluorinated azidopyrimidines and 4-azido-3-chloro-2,5,6-trifluoropyridine,Journal of Fluorine Chemistry,1980年,Vol.16, No.4,p.325-38
MOKHORT,N.A.,Search for non-steroid antiinflammatory substances among heterocyclic anthranilic acid derivatives,Farmatsevtichnii Zhurnal(Kiev),1970年,Vol.25, No.4,p.76-7
BANKS,R.E. et al,Heterocyclic polyfluoro compounds. X. Nucleophilic substitution in tetrafluoropyrimidine,Journal of the Chemical Society [Section] C: Organic,1967年,No.19,p.1822-6
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki