Title:
心房細動モデル動物の作製方法、心房細動を誘発させる方法及び心房細動を誘発させた動物を用いた心房細動抑制剤の評価方法
Document Type and Number:
Japanese Patent JP4704712
Kind Code:
B2
Abstract:
It is intended to conveniently and effectively using an animal model of paroxysmal atrial fibrillation, which shows an onset mechanism similar to that of humans, in screening for the evaluation of the efficacy of an atrial fibrillation inhibitor (an antiarrhythmic). More specifically speaking, atrial fibrillation is reproducibly induced by inserting an electrode catheter into the heart of a dog with complete atrioventricular block and electrically stimulating the sinus node or the interatrial septum. Then an atrial fibrillation inhibitor is administered to the dog with complete atrioventricular block that suffers from atrial fibrillation thus induced and the efficacy of the inhibitor is evaluated.
Inventors:
Atsushi Sugiyama
Takahara Akira
Keitaro Hashimoto
Takahara Akira
Keitaro Hashimoto
Application Number:
JP2004257448A
Publication Date:
June 22, 2011
Filing Date:
September 03, 2004
Export Citation:
Assignee:
Toho University
International Classes:
A01K67/00
Domestic Patent References:
| JP1110345A |
Other References:
Atushi Sugiyama, Yuko Ishida, Yoshihiko Satoh, Shigeki Aoki, Masaaki HOri, Yasuki Akie, Yoshihiko Kobayashi, Keitaro Hashimoto,Electrophysiological, Anatomical and Histological Remodeling of the Heart to AV Block Enhances Susceptibility to Arrhythmogenic Effects of QT-Prolonging Drugs,Japanese Journal of Pharmacology ,日本,日本薬理学会,2002年 3月 1日,Vol.88, No.3,pp.341-350
Jannie Ausma, Nicolle Litjens, Marie-Helene Lenders, Hans Duimel, Frans Mast, Luc Wouters, Frans Ramaekers, Maurits Allessie and Marcel Borgers,Time Course of Atrial Fibrillation-induced Cellular Structural Remodeling in Atria of the Goat,Journal of Molecular and Cellular Cardiology ,2001年12月,Vol.33, No.12,pp.2083-2094
Jannie Ausma, Nicolle Litjens, Marie-Helene Lenders, Hans Duimel, Frans Mast, Luc Wouters, Frans Ramaekers, Maurits Allessie and Marcel Borgers,Time Course of Atrial Fibrillation-induced Cellular Structural Remodeling in Atria of the Goat,Journal of Molecular and Cellular Cardiology ,2001年12月,Vol.33, No.12,pp.2083-2094
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda