Title:
増殖した細胞系およびその使用方法
Document Type and Number:
Japanese Patent JP4741189
Kind Code:
B2
Abstract:
The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.
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Inventors:
Freeman Thomas Bee.
Cabie des Pablo
Cavier des Raul
Samberg Paul Earl.
Cameron Don F.
Cabie des Pablo
Cavier des Raul
Samberg Paul Earl.
Cameron Don F.
Application Number:
JP2003565425A
Publication Date:
August 03, 2011
Filing Date:
February 07, 2003
Export Citation:
Assignee:
University of South Florida
University of Chile
University of Chile
International Classes:
C12N5/075; C12Q1/02; A61K35/12; A61K35/26; A61K45/00; A61P1/16; A61P3/10; A61P5/06; A61P9/10; A61P17/02; A61P19/02; A61P21/02; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07K14/475; C12N5/00; C12N5/06
Other References:
Brain Research,1986年,Vol.365,p.259-268
Journal of Molecular and Cellular Cardiology,1993年,Vol.25,p.829-845
Biochimica et Biophysica Acta,1992年,Vol.1134,p.247-255
European Journal of Neuroscience,2000年,Vol.12,p.3259-3264
Cell Biology International Reports,1985年,Vol.9, No.3,p.209-218
Endocrinology,1976年,Vol.99, No.2,p.549-554
Journal of Molecular and Cellular Cardiology,1993年,Vol.25,p.829-845
Biochimica et Biophysica Acta,1992年,Vol.1134,p.247-255
European Journal of Neuroscience,2000年,Vol.12,p.3259-3264
Cell Biology International Reports,1985年,Vol.9, No.3,p.209-218
Endocrinology,1976年,Vol.99, No.2,p.549-554
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto