Title:
炎症性疾患及び糖尿病の治療のためのグルココルチコイドリガンドとしての1,1,1-トリフルオロ-4-フェニル-4-メチル-2-(1H-ピロロ[2,3-c]ピリジン-2-イルメチル)ペンタン-2-オール誘導体及び関連化合物
Document Type and Number:
Japanese Patent JP4778430
Kind Code:
B2
Abstract:
Compounds of Formula (IA), (IB), (IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
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Inventors:
Beccary Younes
Betagueri Rajashecker
Emmanuel Michael Jay
Hammac Abdel Hakim
Halken christian har yacht yacht
Kiraine Thomas Martin
Kuzmitch Daniel
Lee Thomas Wai Ho
Liu Pin Long
Patel Yousha Earl
Razavi Hossain
Leeter Doris
Hidenori Takahashi
Thomson David S
One Gee
Sindel Rene
Proudfoot John Robert
Betagueri Rajashecker
Emmanuel Michael Jay
Hammac Abdel Hakim
Halken christian har yacht yacht
Kiraine Thomas Martin
Kuzmitch Daniel
Lee Thomas Wai Ho
Liu Pin Long
Patel Yousha Earl
Razavi Hossain
Leeter Doris
Hidenori Takahashi
Thomson David S
One Gee
Sindel Rene
Proudfoot John Robert
Application Number:
JP2006528127A
Publication Date:
September 21, 2011
Filing Date:
September 22, 2004
Export Citation:
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
International Classes:
C07D215/14; A61K31/4745; A61K31/52; A61K31/5377; A61P5/44; A61P5/46; C07D209/08; C07D213/75; C07D237/20; C07D239/42; C07D307/79; C07D319/06; C07D319/08; C07D405/04; C07D405/06; C07D405/10; C07D405/12; C07D405/14; C07D407/06; C07D471/02; C07D471/04; C07D487/04; C07D491/02; C07D491/04; C07D495/04; C07D498/02; A61K31/381; A61K31/404; A61K31/416; A61K31/4355; A61K31/4365; A61K31/437; A61K31/4409; A61K31/454; A61K31/47; A61K31/4709; A61K31/496; A61K31/5025; A61K31/506; A61K31/519; A61P1/04; A61P1/16; A61P3/04; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P17/00; A61P19/02; A61P25/00; A61P25/04; A61P25/28; A61P27/06; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D209/12; C07D213/30; C07D213/85; C07D231/56; C07D333/56; C07D401/06; C07D401/10; C07D403/06; C07D403/10; C07D491/048
Domestic Patent References:
| JP4324480B2 | ||||
| JP2006516256A |
Foreign References:
| WO2003059899A1 |
Attorney, Agent or Firm:
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Atsushi Hakoda
Kenji Asai