Title:
システインプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP4787765
Kind Code:
B2
Abstract:
A compound of the formula II wherein one of R1 and R2 is halo and the other is H or halo; R3 is C1-C4 straight or branched chain, optionally fluorinated, alkyl; R4 is H; or R3 together with R4 and the adjoining backbone carbon defines: a spiro-C5-C7 cycloalkyl, optionally substituted with 1 to 3 substituents selected from halo, hydroxyl, C1-C4 alkyl or C1-C4 haloalkyl; or optionally bridged with a methylene group; or a C4-C6 saturated heterocycle having a hetero atom selected from O, NRa, S, S(═O)2; where Ra is H, C1-C4 alkyl or CH3C(═O); R5 is independently selected from H or methyl; E is —C(═O)—, —S(═O)m—, —NR5S(═O)m—, —NR5C(═O)—, —OC(═O)—, R6 is a stable, optionally substituted, monocyclic or bicyclic, carbocycle or hetorocycle; m is independently 0, 1 or 2; are inhibitors of cathepsin K and useful in the treatment or prophylaxis of osteoporosis.
Inventors:
Magnus Nilsson
Exiao-Exeon Zhou
Rawdes Oden
Bujorn Krasson
Rolf Noren
Ursula Gravoska
Phiripu Jackson
Phirilip Farolone
Andrew Carle
Marc Relayi
Matte tozel
Tony Johnson
Victor Diaz
Lia Crespo
Jucis cangas methosa
Tohierli Bonnaud
Exiao-Exeon Zhou
Rawdes Oden
Bujorn Krasson
Rolf Noren
Ursula Gravoska
Phiripu Jackson
Phirilip Farolone
Andrew Carle
Marc Relayi
Matte tozel
Tony Johnson
Victor Diaz
Lia Crespo
Jucis cangas methosa
Tohierli Bonnaud
Application Number:
JP2006548412A
Publication Date:
October 05, 2011
Filing Date:
January 06, 2005
Export Citation:
Assignee:
MEDIVIR AKTIEBOLAG
International Classes:
C07D491/048; A61K31/407; A61K31/427; A61K31/454; A61K31/496; A61K31/5377; A61P1/02; A61P3/14; A61P19/02; A61P19/10; A61P25/04; A61P29/00; A61P35/00; A61P43/00; C07D491/04
Domestic Patent References:
| JP2003183161A | 2003-07-03 |
Foreign References:
| WO2002057270A1 | 2002-07-25 |
Attorney, Agent or Firm:
Toru Ishikawa