Title:
ピリミドチオフェン化合物
Document Type and Number:
Japanese Patent JP4891904
Kind Code:
B2
Abstract:
Compounds of formula (I) are inhibitors of HSP90, and useful in the treatment of, for example, cancers: wherein R2 is a group of formula (IA): -(Ar1)m-(Alk1)p-(Z)r-(Alk2)s-Q (IA) wherein in any compatible combination Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C3 alkylene or C2-C3 alkenylene radicals, m, p, r and s are independently 0 or 1, Z is -O-, -S-, -(C-O)-, -(C-S)-, -SO2-, -C(-O)O-, -C(-O)NRA-, -C(-S)NRA-, -SO2NRA-, -NRAC(-O)-, -NRASO2- or -NRA- wherein RA is hydrogen or C1-C6 alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R3 is hydrogen, an optional substituent, or an optionally substituted (C1-C6)alkyl, aryl or heteroaryl radical; and R4 is (i) hydrogen, a -CN group, a nitro group -NO2, or a -C(-NOH)(NH2) group, or (ii) an optionally substituted C1-C6alkyl, aryl, heterocyclic, aryl(C1-C6alkyl)-, or heterocyclic(C1-C6alkyl)- group, or (iii) a group of formula -C(-O)R5 wherein R5 is hydroxyl, optionally substituted C1-C6alkyl, C1-C6alkyoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aryl(C1-C6alkyl)-, aryl(C1-C6alkoxy)-, heteroaryl(C1-C6alkyl)-, or heteroaryl(C1-C6alkoxy)-, or (iv) a group of formula -C(-O)NHR6 wherein R6 is primary, secondary, tertiary or cyclic amino, or hydroxyl, optionally substituted C1-C6alkyl, C1-C6alkyoxy, aryl, aryloxy, heteroaryl, heteroaryloxy, aryl(C1-C6alkyl)-, aryl(C1-C6alkoxy)-, heteroaryl(C1-C6alkyl)-, or heteroaryl(C1-C6alkoxy)-.
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Inventors:
Barry-Alonso, Xavier
Blow, Paul, Andrew
Drysdale, martin, james
Web, pole
Dimock, brian, william
Blow, Paul, Andrew
Drysdale, martin, james
Web, pole
Dimock, brian, william
Application Number:
JP2007522013A
Publication Date:
March 07, 2012
Filing Date:
July 18, 2005
Export Citation:
Assignee:
VERNALIS(CAMBRIDGE)LIMITED
CANCER RESEARCH TECHNOLOGY LTD.
CANCER RESEARCH TECHNOLOGY LTD.
International Classes:
C07D495/04; A61K31/519; A61P1/00; A61P3/00; A61P3/10; A61P9/00; A61P11/06; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/14; A61P25/28; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P43/00
Domestic Patent References:
| JP2007533611A | 2007-11-22 |
Foreign References:
| WO2003037860A2 | 2003-05-08 | |||
| US20010027196A1 | 2001-10-04 | |||
| US0340183A | 1886-04-20 |
Attorney, Agent or Firm:
Shintaro Nogawa