Title:
細胞単離方法
Document Type and Number:
Japanese Patent JP4980211
Kind Code:
B2
Abstract:
The present invention relates generally to a method for the generation of a substantially homogenous population of undifferentiated cells. More particularly, the present invention relates to a method for isolating a substantially homogenous population of stem cells, and in particular, mammary stem cells (MaSCs). The MaSCs of the present invention are isolated on the basis of differential levels of proteins present on their cell surface. The MaSCs of the present invention are particularly useful as targets for identifying agents which modulate MaSC survival, self-renewal, proliferation and/or differentiation in both normal and diseased tissue such as, but not limited to, tumor tissue, and, also as source of tissue for the regeneration, replacement and/or augmentation of tissue damaged and/or lost after disease or injury.
Inventors:
Lindeman Jeffrey John
Shackleton mark
Vaillant Francois
Bisvader Jane Ellen
Shackleton mark
Vaillant Francois
Bisvader Jane Ellen
Application Number:
JP2007511777A
Publication Date:
July 18, 2012
Filing Date:
May 12, 2005
Export Citation:
Assignee:
Walter and Eliza Hall Institute of Medical Research
International Classes:
C12N5/074; A61K35/55; A61P43/00; C12N5/071; C12Q1/02; G01N33/15; G01N33/48; G01N33/50; G01N33/543
Foreign References:
| WO2002012447A2 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi