Title:
均一な形態を有するマイクロカプセルの製造方法、並びにこの方法により製造されたマイクロカプセル
Document Type and Number:
Japanese Patent JP5021552
Kind Code:
B2
Abstract:
The invention relates to a process for the production of morphologically uniform microcapsules that contain peptides, proteins or other water-soluble biologically active substances as active ingredients as well as microcapsules that are produced according to this process with a degree of concentration of between 3 to 30% by weight and a diameter<=8 mum.According to the invention, biodegradable polymers are dissolved in a halogen-free solvent or solvent mixture, and the buffered active ingredient solution, which has a pH of between 6.0 to 8.0, is dispersed into this solution. Then, an aqueous solution that contains a surface-active substance (W/O/W-emulsion) is added to this W/O-emulsion, and the solvent is removed.The microcapsules that are produced with this process do not show any tendency toward agglomeration. The encapsulation efficiency of the process is approximately 90 to 95%.
Inventors:
Rusling, Georg
Albayrak, Sheral
Tuck, Johannes
Chemitz, Reinhard
Albayrak, Sheral
Tuck, Johannes
Chemitz, Reinhard
Application Number:
JP2008107032A
Publication Date:
September 12, 2012
Filing Date:
April 16, 2008
Export Citation:
Assignee:
Alrise Biosystems Gezel Shaft Mitt Beschlenktel Haftung
International Classes:
A61K38/00; A61K9/16; A61K9/19; A61K9/50; A61K38/04; A61K38/09; A61K38/21; A61K38/28; A61K38/38; A61K45/08; A61K47/34; B01J13/02; B01J13/12; C07K7/06
Foreign References:
| WO1995013799A1 | ||||
| WO1995011009A1 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Kazumi Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Kazumi Nakamura