アゴメラチン合成の新規な方法

Title:

アゴメラチン合成の新規な方法

Document Type and Number:

Japanese Patent JP5112399

Kind Code:

B2

Abstract:

Process for industrial synthesis of N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide (agomelatine) (I) comprises reacting (7-methoxy-1-naphtyl)acetonitrile, which is subjected to a reduction by hydrogen in the presence of Raney nickel in medium containing acetic anhydride in a polar protic medium to give (I) that is isolated as a solid. ACTIVITY : Antidepressant; Hypnotic; Cardiovascular-Gen.; Gastrointestinal-Gen.; CNS-Gen.; Muscular-Gen.; Eating-Disorders-Gen.; Anorectic. MECHANISM OF ACTION : 5-Hydroxytryptamine 2C receptor antagonist.

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Inventors:

Pascal Bontemperi
Xavier Jalanck
Jerome-Benoit Stark
Jean-Pierre Serie

Application Number:

JP2009182088A

Publication Date:

January 09, 2013

Filing Date:

August 05, 2009

Export Citation:

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Assignee:

Réra Bora Toir Servier

International Classes:

C07C231/06; C07C233/18; C07B61/00

Domestic Patent References:

JP2005247844A
JP2002509130A

Foreign References:

US3062869
FR1141276A1

Attorney, Agent or Firm:

Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito

Previous Patent: JPS5112398

Next Patent: UNMOOYOBISONO KENDAKUTAINO SEIZOHOHO