Title:
デシタビンの液体製剤及びその使用
Document Type and Number:
Japanese Patent JP5129922
Kind Code:
B2
Abstract:
Pharmaceutical formulations, kits and vessels are provided for delivering decitabine to a patient suffering from a disease in need of treatment with decitabine. The pharmaceutical formulation comprises decitabine solvated in a non-aqueous solvent that comprises glycerin, propylene glycol, polyethylene glycol, or combinations. Such formulations are more chemically stable than conventional liquid formulations of decitabine containing more than 40% water in volume. The pharmaceutical formulations can be used for any disease that is sensitive to the treatment with decitabine, such as hematological disorders and cancer.
Inventors:
Joshi Hangar Rajashuri
Zan Shichen
Gon Stephanie
Red Car Sanjeev
Gore Ashok Wai
Zan Shichen
Gon Stephanie
Red Car Sanjeev
Gore Ashok Wai
Application Number:
JP2004510806A
Publication Date:
January 30, 2013
Filing Date:
May 30, 2003
Export Citation:
Assignee:
Astex Pharmaceuticals, Inc.
International Classes:
A61K9/08; A61K31/706; A61K9/00; A61K9/14; A61K9/19; A61K31/7072; A61K45/00; A61K47/02; A61K47/10; A61K47/12; A61K47/18; A61K47/20; A61K47/22; A61K47/26; A61K47/34; A61K47/36; A61K47/40; A61P1/04; A61P7/04; A61P7/06; A61P9/10; A61P17/02; A61P17/06; A61P19/02; A61P21/00; A61P25/02; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P31/22; A61P33/00; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00
Domestic Patent References:
| JP55027077B1 |
Foreign References:
| US4684630 |
Other References:
Meulenbelt-Snijders,S.J.,et al,Pharmaceutisch Weekblad,1984年,Vol.119,pp 1186-1189
Lin,K-T.,et al,Journal of Pharmaceutical Sciences,1981年,Vol.70, No.11,pp 1228-1232
Momparler,R.L.,et al,Cancer Chemotherapy and Pharmacology,1989年,Vol.25,pp 51-54
岡野 定舗 編,新・薬剤学総論,1987年,改訂第3版,第319-335頁
KANETO UEKAWA,Part VII 製薬および製剤上の化学的問題,最新 創薬化学 下巻 THE PRACTICE OF MEDICINAL CHEMISTRY,大塚 賢一郎 株式会社テクノミック
Lin,K-T.,et al,Journal of Pharmaceutical Sciences,1981年,Vol.70, No.11,pp 1228-1232
Momparler,R.L.,et al,Cancer Chemotherapy and Pharmacology,1989年,Vol.25,pp 51-54
岡野 定舗 編,新・薬剤学総論,1987年,改訂第3版,第319-335頁
KANETO UEKAWA,Part VII 製薬および製剤上の化学的問題,最新 創薬化学 下巻 THE PRACTICE OF MEDICINAL CHEMISTRY,大塚 賢一郎 株式会社テクノミック
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama