Title:
前駆/幹細胞を動員する方法
Document Type and Number:
Japanese Patent JP5137288
Kind Code:
B2
Abstract:
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z' (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of formula (a), wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z' may be embodied in a form as defined by Z above, or alternatively may be of the formula -N(R)-(CR2)n-X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; "linker" represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulphur atoms.
Inventors:
Briger, Gary Jay.
Abrams, Michael Jay.
Henson, Jeffrey W..
McFarland, Ronald Trevor
Calandra, Gary Bee.
Dale, David Sea.
Broxmayer, Hal Yi.
Abrams, Michael Jay.
Henson, Jeffrey W..
McFarland, Ronald Trevor
Calandra, Gary Bee.
Dale, David Sea.
Broxmayer, Hal Yi.
Application Number:
JP2003516507A
Publication Date:
February 06, 2013
Filing Date:
July 30, 2002
Export Citation:
Assignee:
Anomed Incorporated
International Classes:
A61K31/395; A61K45/00; A61K31/33; A61K31/496; A61K31/55; A61K31/551; A61K31/555; A61K38/00; A61K38/19; A61P7/00; A61P7/06; A61P17/02; A61P31/04; A61P35/02; A61P37/00; A61P37/04; A61K
Domestic Patent References:
| JP8127539A | ||||
| JP952824A | ||||
| JP9504516A |
Foreign References:
| WO2000045814A1 | ||||
| WO2000002870A1 |
Other References:
HENDRIX,C.W.et al,Antimicrob Agents Chemother,2000年6月,Vol.44,No.6,p.1667-1673
SHEN,H.et al,J Immunol,2001年4月,Vol.166,No.8,p.5027-5033
KAWABATA,K.et al,Proc Natl Acad Sci USA,1999,Vol.96,No.10,p.5663-5667
SHEN,H.et al,J Immunol,2001年4月,Vol.166,No.8,p.5027-5033
KAWABATA,K.et al,Proc Natl Acad Sci USA,1999,Vol.96,No.10,p.5663-5667
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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