Title:
リバビリンを含むワクチンおよびその使用方法
Document Type and Number:
Japanese Patent JP5175417
Kind Code:
B2
Abstract:
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising ribavirin and an antigen, preferably an antigen that has an epitope present in Hepatitis C virus (HCV), are disclosed for use in treating and preventing disease, preferably HCV infection.
Inventors:
Mattberg, Salberg
Furtgren, Catalina
Furtgren, Catalina
Application Number:
JP2002518994A
Publication Date:
April 03, 2013
Filing Date:
August 15, 2001
Export Citation:
Assignee:
Tripep Acti Boraget
International Classes:
C12N15/09; A61K31/7052; A61K31/7056; A61K38/00; A61K39/00; A61K39/29; A61K39/39; A61K48/00; A61P31/14; A61P37/04; C07K14/18; C12N5/10; C12N7/00; C12N7/01; C12N15/40
Domestic Patent References:
| JP5081600B2 |
Foreign References:
| WO1997026883A1 |
Other References:
HULTGREN,C. et al,The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses,J Gen Virol,1998年,Vol.79 , No. Pt 10,p.2381-91
CHIANG B L,Enhancement of hepatitis c virus core antigen-specific type 1 T helper cell response by ribavirin correlates with the increased level of IL-12,FASEB JOURNAL,米国,2000年 4月20日,V14N6,PA949
矢萩則夫ら,C型肝炎の診断と病態解析 HCV抗体検査法と病態解析,臨床病理,1991年,Vol.39, No.6,578-85
ABRIGNANI,S. et al,Perspectives for a vaccine against hepatitis C virus,J Hepatol,1999年,Vol.31 Suppl 1,p.259-63
ZHANG,Z.X. et al,Interferon-alpha treatment induces delayed CD4 proliferative responses to the hepatitis C virus nonstructural protein 3 regardless of the outcome of therapy,J Infect Dis,1997年,Vol.175, No.6,p.1294-301
CHIANG B L,Enhancement of hepatitis c virus core antigen-specific type 1 T helper cell response by ribavirin correlates with the increased level of IL-12,FASEB JOURNAL,米国,2000年 4月20日,V14N6,PA949
矢萩則夫ら,C型肝炎の診断と病態解析 HCV抗体検査法と病態解析,臨床病理,1991年,Vol.39, No.6,578-85
ABRIGNANI,S. et al,Perspectives for a vaccine against hepatitis C virus,J Hepatol,1999年,Vol.31 Suppl 1,p.259-63
ZHANG,Z.X. et al,Interferon-alpha treatment induces delayed CD4 proliferative responses to the hepatitis C virus nonstructural protein 3 regardless of the outcome of therapy,J Infect Dis,1997年,Vol.175, No.6,p.1294-301
Attorney, Agent or Firm:
Tsutomu Toyama
Hidemi Matsukura
Yoshiyuki Kawaguchi
Yutaka Nagata
Hidemi Matsukura
Yoshiyuki Kawaguchi
Yutaka Nagata