Title:
ヒト免疫不全ウイルスの複製阻害薬
Document Type and Number:
Japanese Patent JP5269086
Kind Code:
B2
Abstract:
Compounds of formula I: wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.
Inventors:
Tsantrisos Euraes
Bailey Murray Dee
Birodou francois
Carson Rebecca Jay
Fader Lee
Harmos Teddy
Kawai Stephen
Laundry Serge
La Plante Stephen
Simone Bruno
Bailey Murray Dee
Birodou francois
Carson Rebecca Jay
Fader Lee
Harmos Teddy
Kawai Stephen
Laundry Serge
La Plante Stephen
Simone Bruno
Application Number:
JP2010533395A
Publication Date:
August 21, 2013
Filing Date:
November 03, 2008
Export Citation:
Assignee:
Gilead Sciences Inc.
International Classes:
C07D215/14; C07D215/18; C07D401/04; C07D405/04; C07D405/14; C07D413/04; C07D413/14; C07D417/12; C07D417/14; C07D491/06; A61K31/47; A61K31/4709; A61K31/4741; A61K31/506; A61K31/5377; A61K31/538; A61P31/18
Domestic Patent References:
| JP2009537459A | ||||
| JP2005531554A | ||||
| JP2001518890A |
Foreign References:
| WO1993004047A1 | ||||
| WO2004024693A1 | ||||
| US20050165052 | ||||
| US20060094755 |
Other References:
MEKOUAR,K. et al,Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells,J Med Chem,1998年,Vol.41, No.15,p.2846-57
LAMEIRA,J. et al,Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: A density functional theory study,Bioorganic & Medicinal Chemistry,2006年,Vol.14, No.21,p.7105-7112
LAMEIRA,J. et al,Structure-activity relationship study of flavone compounds with anti-HIV-1 integrase activity: A density functional theory study,Bioorganic & Medicinal Chemistry,2006年,Vol.14, No.21,p.7105-7112
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa