Title:
緑膿菌の薬剤排出ポンプの機能を阻害する方法及び薬剤
Document Type and Number:
Japanese Patent JP5314286
Kind Code:
B2
Abstract:
The purpose of the present invention is to provide a method and an agent to efficiently inhibit the function of the drug efflux pump of Pseudomonas aeruginosa. The invention provides a method to inhibit the function of the drug efflux pump of Pseudomonas aeruginosa, comprising modifying any amino acid residue selected from 100th to 109th or 311th to 320th amino acid residues in the amino acid sequence of mature OprM protein. The invention also provides an agent having such inhibitory effect, and a screening method thereof.
Inventors:
Ryohara Eisaku
Hidetoshi Inoko
Hidetoshi Inoko
Application Number:
JP2007557763A
Publication Date:
October 16, 2013
Filing Date:
February 09, 2007
Export Citation:
Assignee:
Tokai University
International Classes:
C07K14/21; A61K39/395; A61K45/00; A61P31/04; G01N33/15; G01N33/50; C07K16/12; C12N15/09
Domestic Patent References:
| JP2003511074A | 2003-03-25 | |||
| JP2002510463A | 2002-04-09 |
Foreign References:
| WO1999061021A1 | 1999-12-02 |
Other References:
JPN6012010500; Ｗｏｎｇ，Ｋ．Ｋ．Ｙ． ｅｔ ａｌ．: 'Ｅｖａｌｕａｔｉｏｎ ｏｆ ａ ｓｔｒｕｃｔｕｒａｌ ｍｏｄｅｌ ｏｆ Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ ｏｕｔｅｒ ｍｅｍｂｒａｎｅ ｐｒｏｔｅｉｎ ＯｐｒＭ， ａｎ ｅｆｆｌｕｘ ｃｏ' Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８３， Ｎｏ．１, 200101, Ｐ．３６７-３７４
JPN6012010501; Ｗｏｎｇ，Ｋ．Ｋ．Ｙ． ｅｔ ａｌ．: 'Ｉｎｓｅｒｔｉｏｎ ｍｕｔａｇｅｎｅｓｉｓ ａｎｄ ｍｅｍｂｒａｎｅ ｔｏｐｏｌｏｇｙ ｍｏｄｅｌ ｏｆ ｔｈｅ Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ ｏｕｔｅｒ ｍｅｍｂｒａｎｅ ｐｒｏｔｅ' Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８２， Ｎｏ．９, 200005, Ｐ．２４０２-２４１０
JPN6012010501; Ｗｏｎｇ，Ｋ．Ｋ．Ｙ． ｅｔ ａｌ．: 'Ｉｎｓｅｒｔｉｏｎ ｍｕｔａｇｅｎｅｓｉｓ ａｎｄ ｍｅｍｂｒａｎｅ ｔｏｐｏｌｏｇｙ ｍｏｄｅｌ ｏｆ ｔｈｅ Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ ｏｕｔｅｒ ｍｅｍｂｒａｎｅ ｐｒｏｔｅ' Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８２， Ｎｏ．９, 200005, Ｐ．２４０２-２４１０
Attorney, Agent or Firm:
Naoto Uchida
Koji Okuhara
Koji Okuhara