Title:
がんの診断方法と治療方法
Document Type and Number:
Japanese Patent JP5504163
Kind Code:
B2
Abstract:
An object of the present invention is to provide methods for diagnosing and/or treating tumors using HERV-H env gene or HERV-H env protein. Specifically, tumors are diagnosed by detecting expression of HERV-H env gene; and agents for detecting the expression are used as diagnosing agents. Further, tumors are treated by inhibiting function of HERV-H env gene; and agents for inhibiting the function are used as antitumor agents. Furthermore, tumors are treated by administering a peptide having a certain sequence of HERV-H env protein and the like; and the peptide is used as a cancer vaccine.
Inventors:
Chie Kudo
Yutaka Kawakami
Yutaka Kawakami
Application Number:
JP2010529742A
Publication Date:
May 28, 2014
Filing Date:
September 11, 2009
Export Citation:
Assignee:
Keio University
International Classes:
C07K14/15; A61K35/12; A61K35/14; A61K35/15; A61K35/17; A61K35/76; A61K39/00; A61K48/00; A61P35/00; A61P35/02; A61P37/04; C12N5/0783
Domestic Patent References:
| JP2007246451A | 2007-09-27 | |||
| JP2004502407A | 2004-01-29 |
Foreign References:
| EP1338606A1 | 2003-08-27 | |||
| WO2006103562A2 | 2006-10-05 | |||
| WO2008011120A2 | 2008-01-24 |
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JPN6009061710; Ｐａｔｒｉｃ Ｊｅｒｎ ｅｔ． ａｌ．: 'Ｓｅｑｕｅｎｃｅ Ｖａｒｉａｂｉｌｉｔｙ， Ｇｅｎｅ Ｓｔｒｕｃｔｕｒｅ， ａｎｄ Ｅｘｐｒｅｓｓｉｏｎ ｏｆ Ｆｕｌｌ-Ｌｅｎｇｔｈ Ｈｕｍａｎ Ｅｎｄｏｇｅｎｏｕｓ Ｒｅｔｒｏｖｉｒｕｓ Ｈ' Ｊｏｕｒｎａｌ ｏｆ Ｖｉｒｏｌｏｇｙ Ｖｏｌ．７９，Ｎｏ．１０, 2005, Ｐ．６３２５-６３３７
JPN6009061711; Ｎａｔｈａｌｉｅ ｄｅ Ｐａｒｓｅｖａｌ ｅｔ． ａｌ．: 'Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ｔｈｅ Ｔｈｒｅｅ ＨＥＲＶ-Ｈ Ｐｒｏｖｉｒｕｓｅｓ ｗｉｔｈ ａｎ Ｏｐｅｎ Ｅｎｖｅｌｏｐｅ Ｒｅａｄｉｎｇ Ｆｒａｍｅ Ｅｎｃｏｍｐａｓｓｉｎｇ ｔｈｅ' Ｖｉｒｏｌｏｇｙ Ｖｏｌ．２７９, 2001, Ｐ．５５８-５６９
JPN6014006234; Ｊ． Ｍｏｌ． Ｍｅｄ． Ｖｏｌ．８５, 2007, Ｐ．２３-３８
JPN6014006236; Ｃａｎｃｅｒ Ｌｅｔｔｅｒｓ Ｖｏｌ．２３１, 2006, Ｐ．２２８-２３９
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation