Title:
新規な生物活性脂質誘導体、それに対して反応性がある免疫により誘導される物質（ｉｍｍｕｎｅ−ｄｅｒｉｖｅｄｍｏｉｅｔｙ）およびその生産および使用方法
Document Type and Number:
Japanese Patent JP5600252
Kind Code:
B2
Abstract:
Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.
Inventors:
The Roger A サバディニ
William A Garland
ジェネビーブ Hansen
William A Garland
ジェネビーブ Hansen
Application Number:
JP2009513443A
Publication Date:
October 01, 2014
Filing Date:
May 31, 2007
Export Citation:
Assignee:
エルパス, Incorporated Lpath and Inc.
International Classes:
C07F9/10; A61K39/395; A61K45/00; A61K47/24; A61K47/42; A61K47/48; A61P35/00; A61P35/02; C07K1/22; C07K16/44; C12P21/08; C12Q1/02; G01N33/53; G01N33/577; C07K14/795; C12N15/09
Attorney, Agent or Firm:
舛谷 Takeshi