Title:
溶液中におけるタンパク質の安定化
Document Type and Number:
Japanese Patent JP5627832
Kind Code:
B2
Abstract:
Provided are storage containers for proteinaceous pharmaceutical compositions which are characterized in, among other things, comprising (i) a wall portion, wherein an inner wall material thereof is selected from silica-coated glass, silicone-coated glass, polymers of non-cyclic olefins, cycloolefin polymers and cycloolefin/linear olefin copolymers and (ii) one or more closure portions not constituting part of the wall portion, and which contains a formulation of a protein. Also provided are new methods of storing proteinaceous compositions. In one aspect, the stored protein is characterized as having an amino-terminal gamma-carboxyglutamic acid (Gla) domain with 9-12 Gla residues.
Inventors:
ジェンセン、マイケル・ベック
ハンセン、ビルテ・リッケガールド
コルンフェルト、トロエルス
ヤコブセン、キルステン・クラマー
ハンセン、ビルテ・リッケガールド
コルンフェルト、トロエルス
ヤコブセン、キルステン・クラマー
Application Number:
JP2006529638A
Publication Date:
November 19, 2014
Filing Date:
May 21, 2004
Export Citation:
Assignee:
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト
International Classes:
A61K38/43; A61J1/05; A61K9/08; A61K9/19; A61P7/04
Attorney, Agent or Firm:
Masatoshi Kurata
Makoto Nakamura
Toshihiro Fukuhara
Peak Takashi
Toshiro Shirane
Nobuhisa Nogawa
Yukinaga Yasujiro
Naoki Kono
Sunagawa 克
Tatsushi Sato
Okada Kishi
Mihoko Horiuchi
Masanori Takeuchi
Makoto Nakamura
Toshihiro Fukuhara
Peak Takashi
Toshiro Shirane
Nobuhisa Nogawa
Yukinaga Yasujiro
Naoki Kono
Sunagawa 克
Tatsushi Sato
Okada Kishi
Mihoko Horiuchi
Masanori Takeuchi