Title:
遺伝子組換えプロテインＳ組成物
Document Type and Number:
Japanese Patent JP5662149
Kind Code:
B2
Abstract:
A pharmaceutical agent for treating a disease such as inflammatory diseases, blood coagulation diseases associated with deficiency of Protein S has been required. The present invention provides a Protein S composition comprising recombinant Protein S molecules having complex type N-glycoside-linked sugar chains, wherein the Protein S has a higher binding activity to a receptor for advanced glycation end products (hereinafter referred to as "RAGE") than native Protein S present in healthy human blood, and also has a higher ratio of sugar chains in which fucose is not bound to the complex type N-glycoside-linked sugar chains bound to Protein S than native Protein S present in healthy human blood.
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Inventors:
神田 豊
佐藤 宏
山田 剛士
加藤 明文
佐藤 光男
佐藤 宏
山田 剛士
加藤 明文
佐藤 光男
Application Number:
JP2010524746A
Publication Date:
January 28, 2015
Filing Date:
August 12, 2009
Export Citation:
Assignee:
協和発酵キリン株式会社
International Classes:
A61K38/00; C07K14/47; A61P7/02; A61P29/00; A61P43/00; C12N5/10; C12N15/09; C12P21/02
Foreign References:
| WO2003085107A1 | 2003-10-16 | |||
| WO2003085107A1 | 2003-10-16 |
Other References:
JPN6009046971; ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．５７９, 2005, Ｐ．６０２３-６０２６
JPN6009046972; Ｂｌｏｏｄ Ｖｏｌ．１０３， Ｎｏ．４, 2004, Ｐ．１１９２-１２０１
JPN6009046973; Ｔｈｒｏｍｂｏｓｉｓ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１００, 2000, Ｐ．８１-８８
JPN6009046974; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ． Ｖｏｌ．８４, 1987, Ｐ．３４９-３５３
JPN6009046976; Ｊｏｕｒｎａｌ ｏｆ Ｓｕｒｇｉｃａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１４７, 200806, Ｐ．７９-８３
JPN6009046977; ＢＩＯＴＥＣＨＮＯＬＯＧＹ ＡＮＤ ＢＩＯＥＮＧＩＮＥＥＲＩＮＧ Ｖｏｌ．８７， Ｎｏ．５, 2004, Ｐ．６１４-６２２
JPN6009046975; Ｔｈｒｏｍｂｏｓｉｓ ａｎｄ Ｈａｅｍｏｓｔａｓｉｓ Ｖｏｌ．９８, 2007, Ｐ．９０-９６
JPN6009046971; ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．５７９, 2005, Ｐ．６０２３-６０２６
JPN6009046972; Ｂｌｏｏｄ Ｖｏｌ．１０３， Ｎｏ．４, 2004, Ｐ．１１９２-１２０１
JPN6009046973; Ｔｈｒｏｍｂｏｓｉｓ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１００, 2000, Ｐ．８１-８８
JPN6009046974; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ． Ｖｏｌ．８４, 1987, Ｐ．３４９-３５３
JPN6009046976; Ｊｏｕｒｎａｌ ｏｆ Ｓｕｒｇｉｃａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１４７, 200806, Ｐ．７９-８３
JPN6009046977; ＢＩＯＴＥＣＨＮＯＬＯＧＹ ＡＮＤ ＢＩＯＥＮＧＩＮＥＥＲＩＮＧ Ｖｏｌ．８７， Ｎｏ．５, 2004, Ｐ．６１４-６２２
JPN6009046975; Ｔｈｒｏｍｂｏｓｉｓ ａｎｄ Ｈａｅｍｏｓｔａｓｉｓ Ｖｏｌ．９８, 2007, Ｐ．９０-９６
JPN6009046972; Ｂｌｏｏｄ Ｖｏｌ．１０３， Ｎｏ．４, 2004, Ｐ．１１９２-１２０１
JPN6009046973; Ｔｈｒｏｍｂｏｓｉｓ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１００, 2000, Ｐ．８１-８８
JPN6009046974; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ． Ｖｏｌ．８４, 1987, Ｐ．３４９-３５３
JPN6009046976; Ｊｏｕｒｎａｌ ｏｆ Ｓｕｒｇｉｃａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１４７, 200806, Ｐ．７９-８３
JPN6009046977; ＢＩＯＴＥＣＨＮＯＬＯＧＹ ＡＮＤ ＢＩＯＥＮＧＩＮＥＥＲＩＮＧ Ｖｏｌ．８７， Ｎｏ．５, 2004, Ｐ．６１４-６２２
JPN6009046975; Ｔｈｒｏｍｂｏｓｉｓ ａｎｄ Ｈａｅｍｏｓｔａｓｉｓ Ｖｏｌ．９８, 2007, Ｐ．９０-９６
JPN6009046971; ＦＥＢＳ Ｌｅｔｔｅｒｓ Ｖｏｌ．５７９, 2005, Ｐ．６０２３-６０２６
JPN6009046972; Ｂｌｏｏｄ Ｖｏｌ．１０３， Ｎｏ．４, 2004, Ｐ．１１９２-１２０１
JPN6009046973; Ｔｈｒｏｍｂｏｓｉｓ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１００, 2000, Ｐ．８１-８８
JPN6009046974; Ｐｒｏｃ． Ｎａｔｌ． Ａｃａｄ． Ｓｃｉ． ＵＳＡ． Ｖｏｌ．８４, 1987, Ｐ．３４９-３５３
JPN6009046976; Ｊｏｕｒｎａｌ ｏｆ Ｓｕｒｇｉｃａｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１４７, 200806, Ｐ．７９-８３
JPN6009046977; ＢＩＯＴＥＣＨＮＯＬＯＧＹ ＡＮＤ ＢＩＯＥＮＧＩＮＥＥＲＩＮＧ Ｖｏｌ．８７， Ｎｏ．５, 2004, Ｐ．６１４-６２２
JPN6009046975; Ｔｈｒｏｍｂｏｓｉｓ ａｎｄ Ｈａｅｍｏｓｔａｓｉｓ Ｖｏｌ．９８, 2007, Ｐ．９０-９６
Attorney, Agent or Firm:
Hironori Honda
Toshimitsu Ichikawa
古館 Kuniko
Toshimitsu Ichikawa
古館 Kuniko