Title:
活性成分の固体分散体を生産するための改良プロセス
Document Type and Number:
Japanese Patent JP5670023
Kind Code:
B2
Abstract:
The present invention relates to a solid dispersion comprising a biologically active ingredient and a matrix-forming agent, wherein the biologically active ingredient comprises ritonavir and the solid dispersion has been obtained by a process which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element.
Inventors:
ケスラー、トマス
ブレイテンバッハ、ヨルグ
シュミッド、クリストフ
デゲンハルト、マティアス
ローゼンベルグ、ヨルグ
クルール、ハラルド
ベルンドル、ギュンター
ブレイテンバッハ、ヨルグ
シュミッド、クリストフ
デゲンハルト、マティアス
ローゼンベルグ、ヨルグ
クルール、ハラルド
ベルンドル、ギュンター
Application Number:
JP2008557771A
Publication Date:
February 18, 2015
Filing Date:
March 12, 2007
Export Citation:
Assignee:
アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー
International Classes:
A61K9/20; A61K9/14; A61K9/28; A61K9/48; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/44; B29B7/46; B29C48/395; B29C48/405; B29C48/41; B29C48/45; B29C48/455; B29C48/67; B29C48/76
Attorney, Agent or Firm:
In the patent business corporation Kawaguchi 國 case, it is a patent firm.