Title:
非水性担体を用いた徐放性製剤
Document Type and Number:
Japanese Patent JP5744735
Kind Code:
B2
Abstract:
The disclosure provides one component,injectable, sustained release formulations which comprise microspheres containing active pharmaceutical ingredients (e.g., exenatide), wherein the microspheres are suspended in a non-aqueous carrier. The non-aqueous carrier can be an oil, a fractionated oil, triglycerides, diglycerides, monoglycerides, propylene glycol fatty acid diesters, and the like. The formulations offer distinct advantages of long shelf life for the stability and potency of the formulation and sustained release of active pharmaceutical ingredients to reduce the frequency of medication dosing and to increase patient compliance.
Inventors:
Mary El Fuchin
Robin H Lee
Hong Ki
Greg Oateman
Robert N Jennings
Scott H. Coleman
Robin H Lee
Hong Ki
Greg Oateman
Robert N Jennings
Scott H. Coleman
Application Number:
JP2011526233A
Publication Date:
July 08, 2015
Filing Date:
September 04, 2009
Export Citation:
Assignee:
AMYLIN PHARMACEUTICALS,LLC
AstraZeneca Pharmaceuticals LP
AstraZeneca Pharmaceuticals LP
International Classes:
A61K38/00; A61K9/10; A61K47/14; A61K47/26; A61K47/34; A61K47/44; A61P3/10; A61P43/00
Foreign References:
| US20080146490 | ||||
| US20040224030 |
Attorney, Agent or Firm:
Samejima Mutsumi
Kyousei Tamura
Nagatoshi Shinagawa
Kyousei Tamura
Nagatoshi Shinagawa