Title:
創薬に有用な大環状化合物ライブラリーのコンビナトリアル合成
Document Type and Number:
Japanese Patent JP5755530
Kind Code:
B2
Abstract:
A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond; where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond; where part (C) is a bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; and where part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.
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Inventors:
Pierre Delonchamp
Eve dolly
Jill Bertiohm
Backpack Welle
Lyussie Run
Eve dolly
Jill Bertiohm
Backpack Welle
Lyussie Run
Application Number:
JP2011179715A
Publication Date:
July 29, 2015
Filing Date:
August 19, 2011
Export Citation:
Assignee:
Ocera Therapeutics, Inc.
International Classes:
A61K38/00; C07K5/12; A61P7/10; A61P21/02; A61P25/04; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P29/00; A61P31/12; A61P33/06; C07B61/00; C07K1/04; C07K1/06; C07K1/10; C07K5/02; C07K5/083; C07K5/09; C07K5/093; C07K7/54; C07K7/64; C40B40/10
Domestic Patent References:
| JP10512570A | ||||
| JP6505486A |
Foreign References:
| WO1999048913A1 | ||||
| WO1998046631A1 |
Other References:
J. Am. Chem. Soc.,1997年,vol.119, no.51,pp.12697-12698
Int. J. Pept. Protein Res.,1992年,vol.39, no.2,pp.145-160
Int. J. Pept. Protein Res.,1992年,vol.39, no.2,pp.145-160
Attorney, Agent or Firm:
Kurata Masatoshi
Yoshihiro Fukuhara
Nobuhisa Nogawa
Takashi Mine
Naoki Kono
Katsu Sunagawa
Morisezo Iseki
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Yoshihiro Fukuhara
Nobuhisa Nogawa
Takashi Mine
Naoki Kono
Katsu Sunagawa
Morisezo Iseki
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi