Title:
２−［（３，５−ジフルオロ−３’−メトキシ−１，１’−ビフェニル−４−イル）アミノ］ニコチン酸の製造方法
Document Type and Number:
Japanese Patent JP5809630
Kind Code:
B2
Abstract:
This invention is directed to a process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid, which comprises the steps of:
a) providing 3,5-difluoro-3'-methoxybiphenyl-4-amine,
b) preparing and isolating an aminium salt of the 3,5-difluoro-3'-methoxybiphenyl-4-amine, and
c) further reacting the aminium salt of 3,5-difluoro-3'-methoxybiphenyl-4-amine obtained in b) to obtain 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid.
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Inventors:
Maria Carmen Boyx Bernardini
Application Number:
JP2012533527A
Publication Date:
November 11, 2015
Filing Date:
October 14, 2010
Export Citation:
Assignee:
Almirall, S.A.
International Classes:
C07D213/80; C07B61/00; C07C217/80
Domestic Patent References:
| JP2006507336A | ||||
| JP2005526724A |
Foreign References:
| WO2008077639A1 |
Other References:
Yin L et al,Chem Rev,2007年,Vol.107,p.133-173
関雅彦,有機合成化学協会誌,2006年,Vol.64, No.8,p.853-866
関雅彦,有機合成化学協会誌,2006年,Vol.64, No.8,p.853-866
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai